2WTV: Aurora-A Inhibitor Structure

PDB ID: 2WTVDownload
MMDB ID: 79551
PDB Deposition Date: 2009/9/22
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 2WTV: monomeric; determined by author and by software (PISA)
Molecular Components in 2WTV
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase 6 Aurora/ipl1-related Kinase 1, Breast Tumor-amplified Kinase, Aurora-a, Aurora-related Kinase 1, Hark1
(Gene symbol: AURKA)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID
2
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
2
ACETATE IONACETATE ION
4
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303