3JSU: Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP

PDB ID: 3JSUDownload
MMDB ID: 83615
PDB Deposition Date: 2009/9/11
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3JSU: dimeric; determined by author and by software (PISA)
Molecular Components in 3JSU
Label Count Molecule
Proteins (2 molecules)
2
Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine
2
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303