4FEW: Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2

PDB ID: 4FEWDownload
MMDB ID: 100770
PDB Deposition Date: 2012/5/30
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 4FEW: monomeric; determined by author
Molecular Components in 4FEW
Label Count Molecule
Protein (1 molecule)
1
Aminoglycoside 3'-phosphotransferase Apha1-iab
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
KANAMYCIN AKANAMYCIN A
2
1
1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
3
1
SODIUM IONSODIUM ION
4
1
CHLORIDE IONCHLORIDE ION
5
1
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303