3OAD: Design And Optimization Of New Piperidines As Renin Inhibitors

PDB ID: 3OADDownload
MMDB ID: 85949
PDB Deposition Date: 2010/8/5
Updated in MMDB: 2010/11
Experimental Method:
x-ray diffraction
Resolution: 2.17  Å
Source Organism:
Similar Structures:
Biological Unit for 3OAD: dimeric; determined by author and by software (PISA)
Molecular Components in 3OAD
Label Count Molecule
Proteins (2 molecules)
1
Renin
(Gene symbol: REN)
Molecule annotation
1
Renin
(Gene symbol: REN)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-acetyl-d-glucosamineN-acetyl-d-glucosamine
2
1
(3s,4r)-n-[2-chloro-5-(2-methoxyethyl)benzyl]-n-cyclopropyl-4-{6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl}-4-hydroxypiperidine-3-carboxamide(3's,4'r)-6-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-4'-hydroxy-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic Acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303