3E34: Protein farnesyltransferase complexed with FPP and ethylenediamine-scaffold inhibitor 10

PDB ID: 3E34Download
MMDB ID: 70118
PDB Deposition Date: 2008/8/6
Updated in MMDB: 2011/05
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 3E34: monomeric; determined by author
Molecular Components in 3E34
Label Count Molecule
Protein (1 molecule)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
(Gene symbol: Fnta)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
2
1
3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303