4JOA: Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor

PDB ID: 4JOADownload
MMDB ID: 111856
PDB Deposition Date: 2013/3/18
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 4JOA: monomeric; determined by author and by software (PISA)
Molecular Components in 4JOA
Label Count Molecule
Protein (1 molecule)
1
ALK Tyrosine Kinase Receptor
(Gene symbol: ALK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303