4M49: Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

PDB ID: 4M49Download
MMDB ID: 113277
PDB Deposition Date: 2013/8/6
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.052  Å
Source Organism:
Similar Structures:
Biological Unit for 4M49: tetrameric; determined by author and by software (PISA)
Molecular Components in 4M49
Label Count Molecule
Proteins (4 molecules)
4
L-lactate Dehydrogenase a Chain
(Gene symbol: LDHA)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
4
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
2
3
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
3
3
3-(5-amino-6-{[(1R)-1-phenylethyl]amino}pyrazin-2-yl)-4-chlorobenzoic acid3-(5-amino-6-{[(1R)-1-phenylethyl]amino}pyrazin-2-yl)-4-chlorobenzoic acid
4
3
SULFATE IONSULFATE ION
5
1
LACTIC ACIDLACTIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303