Abstract
Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase.
MeSH terms
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Adenosine Triphosphatases / antagonists & inhibitors
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Amides / chemical synthesis*
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Amides / pharmacology*
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Animals
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Bone Resorption / drug therapy*
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Chickens
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Databases, Factual
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Osteoclasts / drug effects
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Osteoclasts / enzymology
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Templates, Genetic
Substances
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Amides
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Enzyme Inhibitors
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Adenosine Triphosphatases