Abstract
Beta-lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse beta-lactamases, especially those in molecular classes A and C. A structure activity relationship (SAR) study of a high-throughput screening lead resulted in the discovery of a potent and selective non-beta-lactam inhibitor of class C beta-lactamases.
MeSH terms
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Molecular Structure
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Piperacillin / antagonists & inhibitors
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Piperacillin / pharmacology
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Rhodanine / analogs & derivatives*
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Rhodanine / chemical synthesis
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Rhodanine / chemistry
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Rhodanine / pharmacology
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Structure-Activity Relationship
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beta-Lactamase Inhibitors*
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beta-Lactamases / classification
Substances
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Enzyme Inhibitors
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beta-Lactamase Inhibitors
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Rhodanine
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beta-Lactamases
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Piperacillin