P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2371-4. doi: 10.1016/s0960-894x(99)00392-3.

Abstract

A series of potent P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I is described.

MeSH terms

  • Amides / chemistry
  • Amides / pharmacology*
  • Calpain / antagonists & inhibitors*
  • Humans
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Recombinant Proteins / antagonists & inhibitors
  • Stereoisomerism

Substances

  • Amides
  • Protease Inhibitors
  • Recombinant Proteins
  • Calpain