Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor

J Med Chem. 1997 Jun 20;40(13):1941-6. doi: 10.1021/jm9701637.
No abstract available

MeSH terms

  • Animals
  • Azepines / chemistry*
  • Azepines / pharmacokinetics
  • Dogs
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacokinetics
  • Metabolic Clearance Rate
  • Pyridazines / chemistry*
  • Pyridazines / pharmacokinetics
  • Serpins / chemical synthesis*
  • Serpins / pharmacokinetics
  • Viral Proteins*

Substances

  • Azepines
  • Enzyme Inhibitors
  • Pyridazines
  • Serpins
  • Viral Proteins
  • interleukin-1beta-converting enzyme inhibitor