Synthesis and activity of selective MMP inhibitors with an aryl backbone

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2815-7. doi: 10.1016/s0960-894x(00)00584-9.

Authors

T E Barta¹, D P Becker, L J Bedell, G A De Crescenzo, J J McDonald, G E Munie, S Rao, H S Shieh, R Stegeman, A M Stevens, C I Villamil

Affiliation

¹ Pharmacia, Department of Medicinal Chemistry, Skokie, IL 60077, USA. barta@netmug.org

PMID: 11133099
DOI: 10.1016/s0960-894x(00)00584-9

Abstract

A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology
Collagenases / chemistry
Collagenases / metabolism
Crystallography, X-Ray
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Humans
Hydroxamic Acids / chemical synthesis
Hydroxamic Acids / pharmacology*
Inhibitory Concentration 50
Matrix Metalloproteinase 1 / chemistry
Matrix Metalloproteinase 1 / metabolism
Matrix Metalloproteinase 13
Matrix Metalloproteinase 2 / chemistry
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase Inhibitors*
Models, Molecular
Structure-Activity Relationship

Substances

Antineoplastic Agents
Enzyme Inhibitors
Hydroxamic Acids
Matrix Metalloproteinase Inhibitors
Collagenases
MMP13 protein, human
Matrix Metalloproteinase 13
Matrix Metalloproteinase 2
Matrix Metalloproteinase 1