Abstract
The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
MeSH terms
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Animals
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Clonidine / pharmacology
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Guinea Pigs
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Histamine Antagonists*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Oximes / isolation & purification*
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Oximes / pharmacology
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Porifera / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Tyrosine / analogs & derivatives*
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Histamine Antagonists
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Oximes
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verongamine
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Tyrosine
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Clonidine