Abstract
The identification of 2-pyridinylguanidines (e.g., 27 and 28) as selective inhibitors of urokinase-type plasminogen activator (uPA) is described. The X-ray crystal structure of 27 has been determined, and modelling has been used to predict binding in the enzyme active site.
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Guanidines / chemistry
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Guanidines / pharmacology*
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Models, Molecular
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Pyridines / chemistry*
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Urokinase-Type Plasminogen Activator / antagonists & inhibitors*
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X-Ray Diffraction
Substances
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Enzyme Inhibitors
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Guanidines
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Pyridines
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Urokinase-Type Plasminogen Activator
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pyridine