Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series

J Med Chem. 1993 Jan 22;36(2):300-3. doi: 10.1021/jm00054a018.
No abstract available

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / pharmacology
  • Amino Acid Sequence
  • Amino Acids / chemical synthesis*
  • Amino Acids / pharmacology
  • Animals
  • Antithrombins / chemical synthesis*
  • Antithrombins / pharmacology
  • Dipeptides / chemical synthesis*
  • Dipeptides / pharmacology
  • Molecular Sequence Data
  • Rats
  • Structure-Activity Relationship
  • Thrombin / antagonists & inhibitors*

Substances

  • Aldehydes
  • Amino Acids
  • Antithrombins
  • Dipeptides
  • BMY 44621
  • Thrombin