Wake-promoting agents: search for next generation modafinil: part IV

Philippe Louvet; Dominique Schweizer; Marie-Edith Gourdel; Eric Riguet; Christoph Yue; Val R Marcy; Yin Guo Lin; John Gruner; Brigitte Lesur; Edward R Bacon; Sankar Chatterjee

doi:10.1016/j.ejmech.2012.05.038

Wake-promoting agents: search for next generation modafinil: part IV

Eur J Med Chem. 2012 Aug:54:949-51. doi: 10.1016/j.ejmech.2012.05.038. Epub 2012 Jun 8.

Authors

Philippe Louvet¹, Dominique Schweizer, Marie-Edith Gourdel, Eric Riguet, Christoph Yue, Val R Marcy, Yin Guo Lin, John Gruner, Brigitte Lesur, Edward R Bacon, Sankar Chatterjee

Affiliation

¹ Cephalon (France), Paris, France.

PMID: 22749190
DOI: 10.1016/j.ejmech.2012.05.038

Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of diphenyl ether derived wakefulness enhancing agents (in rat) was developed. From this work, racemic compound 16 was separated into its chiral enantiomers to profile them individually.

MeSH terms

Animals
Benzhydryl Compounds / chemistry
Benzhydryl Compounds / pharmacology*
Cytochrome P-450 Enzyme Inhibitors
Drug Discovery
Humans
Modafinil
Rats
Wakefulness / drug effects*

Substances

Benzhydryl Compounds
Cytochrome P-450 Enzyme Inhibitors
Modafinil