Abstract
Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrogates for cis-amide bonds in a series of boronate ester thrombin inhibitors.
MeSH terms
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Amides / chemistry
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Amides / pharmacology*
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Binding Sites
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Boronic Acids / chemistry
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Boronic Acids / pharmacology*
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Crystallography, X-Ray
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Indicators and Reagents
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Models, Molecular
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Molecular Structure
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
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Tetrazoles / chemical synthesis
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Tetrazoles / chemistry
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Tetrazoles / pharmacology*
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Thrombin / antagonists & inhibitors*
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Thrombin / chemistry*
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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Amides
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Boronic Acids
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Indicators and Reagents
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Pyrazoles
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Tetrazoles
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Triazoles
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Thrombin