Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities

Mai T T Nguyen; Tho H Le; Hai X Nguyen; Phu H Dang; Truong N V Do; Manabu Abe; Ryukichi Takagi; Nhan T Nguyen

doi:10.1021/acs.jnatprod.7b00453

Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities

J Nat Prod. 2017 Dec 22;80(12):3172-3178. doi: 10.1021/acs.jnatprod.7b00453. Epub 2017 Dec 11.

Authors

Mai T T Nguyen, Tho H Le, Hai X Nguyen, Phu H Dang, Truong N V Do, Manabu Abe¹, Ryukichi Takagi¹, Nhan T Nguyen

Affiliation

¹ Department of Chemistry, Graduate School of Science, Hiroshima University , Higashi-Hiroshima, Hiroshima 739-8526, Japan.

PMID: 29227656
DOI: 10.1021/acs.jnatprod.7b00453

Abstract

Phytochemical analysis of an EtOAc extract of the stems of Artocarpus rigida led to the identification of seven new prenylated 4-chromenones, artocarmins G-M (1-7), and nine known compounds (8-17). Their structures were identified based on physical data analysis. In the tyrosinase inhibitory activity test, norartocarpetin (8) displayed the strongest effect, with an IC₅₀ value of 0.023 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Artocarpus / chemistry*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Flavonoids / chemistry
Flavonoids / pharmacology
Monophenol Monooxygenase / antagonists & inhibitors*
Plant Extracts / chemistry*
Plant Extracts / pharmacology*
Prenylation

Substances

Enzyme Inhibitors
Flavonoids
Plant Extracts
Monophenol Monooxygenase