Abstract
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Canavalia / enzymology
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Models, Molecular
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Molecular Structure
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Molybdenum / chemistry*
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Organoselenium Compounds / chemical synthesis*
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Organoselenium Compounds / chemistry
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Organoselenium Compounds / pharmacology*
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Thiourea / chemical synthesis*
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Thiourea / chemistry
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Thiourea / pharmacology*
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Urea / analogs & derivatives*
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Urea / chemical synthesis
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Urea / chemistry
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Urea / pharmacology
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Urease / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Organoselenium Compounds
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selenourea
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Molybdenum
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Urea
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tetrathiomolybdate
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Urease
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Thiourea