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1CZS: crystal structure of the c2 domain of human coagulation factor v: complex with phenylmercury (10.1038/46594 )
1CZT: crystal structure of the c2 domain of human coagulation factor v (10.1038/46594 )
1CZV: crystal structure of the c2 domain of human coagulation factor v: dimeric crystal form (10.1038/46594 )
1EZQ: crystal structure of human coagulation factor xa complexed with rpr128515 (10.1021/JM000940U )
1F0R: crystal structure of human coagulation factor xa complexed with rpr208815 (10.1021/JM000940U )
1F0S: crystal structure of human coagulation factor xa complexed with rpr208707 (10.1021/JM000940U )
1FAX: coagulation factor xa inhibitor complex (10.1074/JBC.271.47.29988 )
1FJS: crystal structure of the inhibitor zk-807834 (ci-1031) complexed with factor xa (10.1021/BI001477Q )
1G2L: factor xa inhibitor complex (10.1016/S0969-2126(00)00551-7 )
1G2M: factor xa inhibitor complex (10.1016/S0969-2126(00)00551-7 )
1HCG: structure of human des(1-45) factor xa at 2.2 angstroms resolution (10.1006/JMBI.1993.1441 )
1IOE: human coagulation factor xa in complex with m55532 27-nov-07 1ioe 1 title
1IQE: human coagulation factor xa in complex with m55590 27-nov-07 1iqe 1 title
1IQF: human coagulation factor xa in complex with m55165 27-nov-07 1iqf 1 title
1IQG: human coagulation factor xa in complex with m55159 27-nov-07 1iqg 1 title
1IQH: human coagulation factor xa in complex with m55143 27-nov-07 1iqh 1 title
1IQI: human coagulation factor xa in complex with m55125 27-nov-07 1iqi 1 title
1IQJ: human coagulation factor xa in complex with m55124 27-nov-07 1iqj 1 title
1IQK: human coagulation factor xa in complex with m55113 27-nov-07 1iqk 1 title
1IQL: human coagulation factor xa in complex with m54476 27-nov-07 1iql 1 title
1IQM: human coagulation factor xa in complex with m54471 27-nov-07 1iqm 1 title
1IQN: human coagulation factor xa in complex with m55192 27-nov-07 1iqn 1 title
1KSN: crystal structure of human coagulation factor xa complexed with fxv673 (10.1016/S0960-894X(02)00213-5 )
1LPG: crystal structure of fxa in complex with 79. (10.1021/JM0111346 )
1LPK: crystal structure of fxa in complex with 125. (10.1021/JM0111346 )
1LPZ: crystal structure of fxa in complex with 41. (10.1021/JM0111346 )
1LQD: crystal structure of fxa in complex with 45. (10.1021/JM0111346 )
1MQ5: crystal structure of 3-chloro-n-[4-chloro-2-[[(4-chlorophenyl) amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2- thiophenecarboxamide complexed with human factor xa (10.1021/BI0264061 )
1MQ6: crystal structure of 3-chloro-n-[4-chloro-2-[[(5-chloro-2-pyridinyl) amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazolyl) methylamino]methyl]-2-thiophenecarboxamide complexed with human factor xa (10.1021/BI0264061 )
1NFU: crystal structure of human coagulation factor xa complexed with rpr132747 (10.1021/JM0203837 )
1NFW: crystal structure of human coagulation factor xa complexed with rpr209685 (10.1021/JM0203837 )
1NFX: crystal structure of human coagulation factor xa complexed with rpr208944 (10.1021/JM0203837 )
1NFY: crystal structure of human coagulation factor xa complexed with rpr200095 (10.1021/JM0203837 )
1P0S: crystal structure of blood coagulation factor xa in complex with ecotin m84r (10.1021/BI027320A )
1SDD: crystal structure of bovine factor vai (10.1073/PNAS.0403072101 )
1V3X: factor xa in complex with the inhibitor 1-[6-methyl-4,5,6,7- tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2- carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine (10.1021/JM049884D )
1WU1: factor xa in complex with the inhibitor 4-[(5-chloroindol-2-yl) sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2- yl]carbonyl]piperazine (10.1016/J.BMC.2005.04.006 )
1XKA: factor xa complexed with a synthetic inhibitor fx-2212a,(2s)-(3'- amidino-3-biphenylyl)-5-(4-pyridylamino)pentanoic acid (10.1073/PNAS.95.12.6630 )
1XKB: factor xa complexed with a synthetic inhibitor fx-2212a,(2s)-(3'- amidino-3-biphenylyl)-5-(4-pyridylamino)pentanoic acid (10.1073/PNAS.95.12.6630 )
1Z6E: factor xa in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol- 5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2- fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; dpc906; bms-561389) (10.1021/JM0497949 )
2BMG: crystal structure of factor xa in complex with 50 (10.1021/JM049187L )
2BOH: crystal structure of factor xa in complex with compound "1" (10.1021/JM0490540 )
2BOK: factor xa - cation (10.1002/ANIE.200500883 )
2BQ6: crystal structure of factor xa in complex with 21 (10.1021/JM0490540 )
2BQ7: crystal structure of factor xa in complex with 43 (10.1021/JM0490540 )
2BQW: crystal structure of factor xa in complex with compound 45 (10.1021/JM0490540 )
2CJI: crystal structure of a human factor xa inhibitor complex (10.1016/J.BMCL.2006.04.053 )
2D1J: factor xa in complex with the inhibitor 2-[[4-[(5- chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide (10.1016/J.BMC.2005.04.006 )
2EI6: factor xa in complex with the inhibitor (-)-cis-n1-[(5- chloroindol-2-yl)carbonyl]-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediamine (10.1016/J.BMCL.2007.05.068 )
2EI7: factor xa in complex with the inhibitor trans-n1-[(5-chloroindol-2- yl)carbonyl]-n2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin- 2-yl)carbonyl]-1,2-cyclohexanediamine
2EI8: factor xa in complex with the inhibitor (1s,2r,4s)-n1-[(5- chloroindol-2-yl)carbonyl]-4-(n,n-dimethylcarbamoyl)-n2- [(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl) carbonyl]-1,2-cyclohexanediamine
2FZZ: factor xa in complex with the inhibitor 1-(3-amino-1,2- benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl) methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6- tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one (10.1016/J.BMCL.2006.02.069 )
2G00: factor xa in complex with the inhibitor 3-(6-(2'-((dimethylamino) methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro- 1h-pyrazolo[3,4-c]pyridin-1-yl)benzamide (10.1016/J.BMCL.2006.08.027 )
2GD4: crystal structure of the antithrombin-s195a factor xa-pentasaccharide complex (10.1038/SJ.EMBOJ.7601089 )
2H9E: crystal structure of fxa/selectide/napc2 ternary complex (10.1016/J.JMB.2006.11.040 )
2J2U: crystal structure of a human factor xa inhibitor complex (10.1016/J.BMCL.2006.08.092 )
2J34: crystal structure of a human factor xa inhibitor complex (10.1016/J.BMCL.2006.08.092 )
2J38: crystal structure of a human factor xa inhibitor complex (10.1016/J.BMCL.2006.08.092 )
2J4I: crystal structure of a human factor xa inhibitor complex (10.1016/J.BMCL.2006.09.001 )
2J94: crystal structure of a human factor xa inhibitor complex (10.1021/JM060870C )
2J95: crystal structure of a human factor xa inhibitor complex (10.1021/JM060870C )
2JKH: factor xa - cation inhibitor complex (10.1002/ANIE.200804695 )
2P16: factor xa in complex with the inhibitor apixaban (bms- 562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1- piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4- c]pyridine-3-carboxamide (10.1021/JM070245N )
2P3F: crystal structure of the factor xa/nap5 complex (10.1016/J.JMB.2007.05.042 )
2P3T: crystal structure of human factor xa complexed with 3- chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2- carboxylic acid [4-chloro-2-(5-chloro-pyridin-2- ylcarbamoyl)-6-methoxy-phenyl]-amide (10.1021/JM070125F )
2P3U: crystal structure of human factor xa complexed with 3- chloro-n-(4-chloro-2-{[(5-chloropyridin-2-yl) amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1h-imidazol- 2-yl)methyl]thiophene-2-carboxamide {pfizer 320663}
2P93: factor xa in complex with the inhibitor 5-chloro-n-(2-(4-(2- oxopyridin-1(2h)-yl)benzamido)ethyl)thiophene-2-carboxamide (10.1016/J.BMCL.2007.06.029 )
2P94: factor xa in complex with the inhibitor 3-chloro-n-((1r,2s)- 2-(4-(2-oxopyridin-1(2h)-yl)benzamido)cyclohexyl)-1h- indole-6-carboxamide (10.1016/J.BMCL.2007.06.029 )
2P95: factor xa in complex with the inhibitor 5-chloro-n-((1r,2s)-2-(4-(2- oxopyridin-1(2h)-yl)benzamido) cyclopentyl)thiophene-2-carboxamide (10.1016/J.BMCL.2007.06.029 )
2PHB: an orally efficacious factor xa inhibitor (10.1111/J.1747-0285.2007.00539.X )
2PR3: factor xa inhibitor (10.1111/J.1747-0285.2007.00520.X )
2Q1J: the discovery of glycine and related amino acid-based factor xa inhibitors (10.1016/J.BMC.2006.02.040 )
2RA0: x-ray structure of fxa in complex with 7-fluoroindazole (10.1021/JM701217R )
2UWL: selective and dual action orally active inhibitors of thrombin and factor xa (10.1016/J.BMCL.2007.03.080 )
2UWO: selective and dual action orally active inhibitors of thrombin and factor xa (10.1016/J.BMCL.2007.03.080 )
2UWP: factor xa inhibitor complex (10.1016/J.BMCL.2007.03.080 )
2VH0: structure and property based design of factor xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs (10.1016/J.BMCL.2007.11.019 )
2VH6: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs (10.1016/J.BMCL.2007.11.023 )
2VVC: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VVU: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VVV: aminopyrrolidine-related triazole factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VWL: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VWM: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VWN: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2VWO: aminopyrrolidine factor xa inhibitor (10.1016/J.EJMECH.2008.12.025 )
2W26: factor xa in complex with bay59-7939 22-mar-17 2w26 1 title (10.1021/JM050101D )
2W3I: crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2 (10.1016/J.BMC.2009.01.063 )
2W3K: crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1 (10.1016/J.BMC.2009.01.063 )
2WYG: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs (10.1016/J.BMCL.2009.11.077 )
2WYJ: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with monoaryl p4 motifs (10.1016/J.BMCL.2009.11.077 )
2XBV: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XBW: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XBX: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XBY: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XC0: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XC4: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2XC5: factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor (10.1016/J.BMCL.2010.06.126 )
2Y5F: factor xa - cation inhibitor complex (10.1002/CHEM.201102571 )
2Y5G: factor xa - cation inhibitor complex (10.1002/CHEM.201102571 )
2Y5H: factor xa - cation inhibitor complex (10.1002/CHEM.201102571 )
2Y7X: the discovery of potent and long-acting oral factor xa inhibitors with tetrahydroisoquinoline and benzazepine p4 motifs (10.1016/J.BMCL.2011.01.129 )
2Y7Z: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs (10.1016/J.BMCL.2011.01.131 )
2Y80: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs (10.1016/J.BMCL.2011.01.131 )
2Y81: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs (10.1016/J.BMCL.2011.01.131 )
2Y82: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs (10.1016/J.BMCL.2011.01.131 )
3CEN: factor xa in complex with the inhibitor n-(2-(((5-chloro-2- pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2h)- pyridinyl)benzamide (10.1016/J.BMCL.2008.03.092 )
3CS7: factor xa in complex with the inhibitor 1-(4-methoxyphenyl)- 6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3- (trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4h)-one (10.1016/J.BMCL.2008.05.095 )
3ENS: crystal structure of human fxa in complex with methyl (2z)-3-[(3- chloro-1h-indol-7-yl)amino]-2-cyano-3-{[(3s)-2-oxo-1-(2-oxo-2- pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate (10.1021/JM800855X )
3FFG: factor xa in complex with the inhibitor (r)-6-(2'-((3- hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4, 5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3- (trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4h)-one (10.1016/J.BMCL.2010.01.011 )
3HPT: crystal structure of human fxa in complex with (s)-2-cyano-1-(2- methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl) azepan-3-yl)guanidine (10.1016/J.BMCL.2009.06.014 )
3IIT: factor xa in complex with a cis-1,2-diaminocyclohexane derivative (10.1016/J.BMC.2009.10.024 )
3K9X: x-ray crystal structure of human fxa in complex with (s)-n-((2- methylbenzofuran-5-ylamino)(2-oxo-1-(2-oxo-2- (pyrrolidin-1-yl) ethyl)azepan-3- ylamino)methylene)nicotinamide (10.1016/J.BMCL.2009.10.084 )
3KL6: discovery of tetrahydropyrimidin-2(1h)-one derivative tak-442: a potent, selective and orally active factor xa inhibitor (10.1021/JM901699J )
3KQB: factor xa in complex with the inhibitor n-(3-fluoro-2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4- triazol-3-yl)phenyl)-3-(trifluoromethyl)-1h- pyrazole-5-carboxamide (10.1016/J.BMCL.2010.01.011 )
3KQC: factor xa in complex with the inhibitor 6-(2'- (methylsulfonyl) biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl) phenyl)-3-(trifluoromethyl)-5,6- dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4h)-one (10.1016/J.BMCL.2010.01.011 )
3KQD: factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1, 2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4- yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)- one (10.1016/J.BMCL.2010.01.011 )
3KQE: factor xa in complex with the inhibitor 3-methyl-1-(3-(5- oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1-ylmethyl) biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)-one (10.1016/J.BMCL.2010.01.011 )
3LIW: factor xa in complex with (r)-2-(1-adamantylcarbamoylamino)- 3-(3-carbamidoyl-phenyl)-n-phenethyl-propionic acid amide (10.1515/BC.2002.130 )
3M36: factor xa in complex with the inhibitor 1-[3-(aminomethyl) phenyl]-n-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3- (trifluoromethyl)-1h-pyrazole-5-carboxamide (dpc423)
3M37: factor xa in complex with the inhibitor 1-[2-(aminomethyl) phenyl]-n-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3- (trifluoromethyl)-1h-pyrazole-5-carboxamide (dpc602)
3P6Z: structural basis of thrombin mediated factor v activation: essential role of the hirudin-like sequence glu666-glu672 for processing at the heavy chain-b domain junction (10.1182/BLOOD-2010-10-315309 )
3P70: structural basis of thrombin-mediated factor v activation: essential role of the hirudin-like sequence glu666-glu672 for processing at the heavy chain-b domain junction (10.1182/BLOOD-2010-10-315309 )
3Q3K: factor xa in complex with a phenylenediamine derivative (10.1016/J.BMCL.2011.01.132 )
3SW2: x-ray crystal structure of human fxa in complex with 6-chloro-n-((3s)- 2-oxo-1-(2-oxo-2-((5s)-8-oxo-5,6-dihydro-1h-1,5-methanopyrido[1,2- a][1,5]diazocin-3(2h,4h,8h)-yl)ethyl)piperidin-3-yl)naphthalene-2- sulfonamide (10.1016/J.BMCL.2011.06.098 )
3TK5: factor xa in complex with d102-4380
3TK6: factor xa in complex with d46-5241
4A7I: factor xa in complex with a potent 2-amino-ethane sulfonamide inhibitor (10.1002/ANIE.201107091 )
4BTI: factor xa in complex with the dual thrombin-fxa inhibitor 58. (10.1021/JM4005835 )
4BTT: factor xa in complex with the dual thrombin-fxa inhibitor 31. (10.1021/JM4005835 )
4BTU: factor xa in complex with the dual thrombin-fxa inhibitor 57. (10.1021/JM4005835 )
4Y6D: factor xa complex with gtc000101
4Y71: factor xa complex with gtc000398
4Y76: factor xa complex with gtc000401 (10.1021/JM060870C )
4Y79: factor xa complex with gtc000406 (10.1021/JM060870C )
4Y7A: factor xa complex with gtc000422
4Y7B: factor xa complex with gtc000441
4YNZ: structure of the n-terminal domain of sad (10.1038/NCOMMS9953 )
4YOM: structure of sad kinase (10.1038/NCOMMS9953 )
4ZH8: factor xa complex with gtc000006
4ZHA: factor xa complex with gtc000102
5K0H: human factor xa in complex with synthetic inhibitor benzylsulfonyl- dser(benzyl)-gly-4-amidinobenzylamide (10.2174/157340606777724040 )
5VOE: desgla-xas195a bound to aptamer 11f7t (10.1038/NBT.4153 )
5VOF: desgla-xas195a bound to aptamer 11f7t and rivaroxaban (10.1038/NBT.4153 )