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BindingDB is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules. BindingDB contains 2,096,653 binding data, for 8,185 protein targets and 920,703 small molecules.

There are 2823 protein-ligand crystal structures with BindingDB affinity measurements for proteins with 100% sequence identity, and 8263 crystal structures allowing proteins to 85% sequence identity.

Simple Search
Article Titles, Authors, Assays, Compound Names, Target Names

Use ? for single-letter wild-card or * for general wild-card.
For example, "adeny*" or "adeny?". Query cannot start with wild card.
Advanced Search Combine multiple search criteria, such as chemical structures, target names, and numerical affinities; restrict searches by data source, such as BindingDB, ChEMBL, PubChem, and Patents.
  1. BindingDB is creating a focused collection of data on SARS-COV-2 and other coronaviruses. This is a work in progress! Please recommend useful papers or patents you may find, and let us know of any possible improvements.
Patent Curation
by BindingDB

BindingDB curates US Patents with protein-small molecule binding data. As of December 2020, BindingDB's patent dataset comprises:

  1. Patents: 4,329
  2. Binding measurements: 635,207
  3. Compounds: 327,787
  4. Target proteins: 1,927
  5. Assays: 6,268
  6. Average Number of Targets per Patent: 1.90
Journal Curation
by BindingDB
BindingDB continually curates a set of journals not covered by other public databases. As of December 2020, the status of our current curation effort is as follows:
  1. ACS Chemical Biology 2006-2017 (vol 1-12) magnifying glass
  2. ACS BioChemistry 1965-2017 (vol 4-56) magnifying glass
  3. Bioorganic Chemistry 1990-2017 (vol 18-73) magnifying glass
  4. BMC Chemical Biology 2001-2010 (vol 1-10) magnifying glass
  5. ChemBioChem 2001-2017 (vol 2-18) magnifying glass
  6. Chemical Biology & Drug Design 2006-2017 (vol 67-89) magnifying glass
  7. Chemistry & Biology 1995-2015 (vol 2-22) magnifying glass
  8. Journal of Biological Chemistry 1982-2014 (vol 257-289) magnifying glass
  9. Journal of Chemical Biology 2010-2010 (vol 3-3) magnifying glass
  10. Journal of Enzyme Inhibition and Medicinal Chemistry 2002-2014 (vol 17-29) magnifying glass
  11. Nature Chemical Biology 2005-2017 (vol 1-13) magnifying glass
  12. Medicinal Chemistry Research 2004-2014 (vol 13-23) magnifying glass
  1. PubMed IDs: 3,445
  2. Binding measurements: 110,319
  3. Compounds: 45,947
  4. Target proteins: 2,992
  5. Assays: 3,224
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Video Tutorials
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  2. Download all data for a target of interest
  3. Find and view all data for a target of interest
  4. Find my compound's targets