BindingDB PrimarySearch_ki

Found 351 with Last Name = 'abdel-halim' and Initial = 'm'

Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592246(T3-CLK)

IC50: 0.670nMAssay Description:Inhibition of N-terminal FLAG-tagged human Clk1 using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured af...More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566435(CHEMBL4872902)

IC50: 1nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592247(CHEMBL5200367)

IC50: 1.10nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRSR peptide ...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50239782(CHEMBL4082113)

IC50: 2.30nMAssay Description:Inhibition of recombinant GST-tagged mouse CLK4 using GRSRSRSRSRSR as substrate after 30 mins in presence of [gamma-32P]-ATP by scintillation countin...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592247(CHEMBL5200367)

IC50: 2.40nMAssay Description:Inhibition of human recombinant GST-tagged Clk2 expressed in Baculovirus expression system using GRSRSRSRSRSRSRSR peptide as substrate preincubated f...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 3nMAssay Description:Inhibition of human full length His-tagged PDE5A1 expressed in baculovirus infected Sf9 insect cells using [3H]-cGMP as substrate preincubated for 15...More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469211(CHEMBL4283503)

IC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592235(CHEMBL5205505)

IC50: 4nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRS peptide a...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566443(CHEMBL4879176)

IC50: 4nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)

IC50: 4nMAssay Description:Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)

IC50: 4.90nMAssay Description:Inhibition of human PDE5A1 catalytic domain (Glu535 to Gln860 residues) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate preincubated ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK4(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592236(CHEMBL5206943)

IC50: 6.60nMAssay Description:Inhibition of human recombinant GST tagged full length CLK4 expressed in Baculovirus expression system at 1 uMMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50239782(CHEMBL4082113)

IC50: 6.90nMAssay Description:Inhibition of recombinant human GST-tagged Clk1 expressed in Escherichia coli using RS repeat substrate peptide after 15 mins in presence of [gamma-3...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592248(CHEMBL5178079)

IC50: 8nMAssay Description:Inhibition of human recombinant Clk1 (130 to end residues) using ERMRPRKRQGSVR peptide as substrate incubated for 40 mins in presence of [gamma 32P-A...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592236(CHEMBL5206943)

IC50: 9.70nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRS peptide a...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50026622(CHEMBL408982)

IC50: 12nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Dyrk1A expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592248(CHEMBL5178079)

IC50: 12nMAssay Description:Inhibition of human recombinant Clk4 (128 to end residues) using YRRAAVPPSPSLS peptide as substrate incubated for 40 mins in presence of [gamma 32P-A...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase haspin(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466167(CHEMBL4278808)

IC50: 12nMAssay Description:Inhibition of Haspin (unknown origin) after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592249(CHEMBL5191395)

IC50: 13nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRSR peptide ...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466158(CHEMBL4290247)

IC50: 14nMAssay Description:Inhibition of recombinant human Dyrk1A expressed in Baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466158(CHEMBL4290247)

IC50: 14nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466158(CHEMBL4290247)

IC50: 14nMAssay Description:Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50026622(CHEMBL408982)

IC50: 15nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Clk4 expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide a...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466168(CHEMBL4282366)

IC50: 15nMAssay Description:Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592246(T3-CLK)

IC50: 15nMAssay Description:Inhibition of N-terminal FLAG-tagged human Clk2 using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured af...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50026622(CHEMBL408982)

IC50: 15nMAssay Description:Inhibition of GST-tagged mouse CLK4 expressed in Escherichia coli using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH as substrate after 10 mins in presence o...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592237(CHEMBL5172542)

IC50: 18nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRS peptide a...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469213(CHEMBL4278353)

IC50: 18nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50239782(CHEMBL4082113)

IC50: 19nMAssay Description:Inhibition of recombinant GST-tagged mouse CLK2 using GRSRSRSRSRSR as substrate after 30 mins in presence of [gamma-32P]-ATP by scintillation countin...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Mus musculus)
German University In Cairo

Curated by ChEMBL

PNG

BDBM50026622(CHEMBL408982)

IC50: 20nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Clk1 expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide a...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592248(CHEMBL5178079)

IC50: 20nMAssay Description:Inhibition of human recombinant Clk2 (138 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presence of [gamma 32P-...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50599470(CHEMBL5179796)

IC50: 20nMAssay Description:Inhibition of human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21 (DE3) using KKISGRLSPIMTEQ as substrate incubated in presence of...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566440(CHEMBL4863072)

IC50: 20nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592238(CHEMBL5191525)

IC50: 21nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRS peptide a...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566438(CHEMBL4852714)

IC50: 21nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466164(CHEMBL4283474)

IC50: 24nMAssay Description:Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566437(CHEMBL4867870)

IC50: 29nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469215(CHEMBL4281810)

IC50: 30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50592239(CHEMBL5183331)

IC50: 35nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRS peptide a...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase haspin(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466158(CHEMBL4290247)

IC50: 36nMAssay Description:Inhibition of recombinant human Haspin expressed in Baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50466157(CHEMBL4294049)

IC50: 37nMAssay Description:Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATPMore data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50316422((5R,11aR)-5-(2-Bromophenyl)-2-ethyl-5,6,11,11a-tet...)

IC50: 38nMAssay Description:Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50566439(CHEMBL4869439)

IC50: 40nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50316440((6R,12aS)-2-Benzyl-6-(2-bromophenyl)-2,3,6,7,12,12...)

IC50: 40nMAssay Description:Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469218(CHEMBL4287985)

IC50: 43nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469214(CHEMBL4292442)

IC50: 43nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50469211(CHEMBL4283503)

IC50: 43nMAssay Description:Inhibition of DYRK1A in human HeLa cells harboring GFP-SF3b1-NT assessed as reduction in SF3b1 phosphorylation at T343 residue after 18 hrs by Wester...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50599469(CHEMBL5179350)

IC50: 45nMAssay Description:Inhibition of human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21 (DE3) using KKISGRLSPIMTEQ as substrate incubated in presence of...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL

PNG

BDBM50239783(CHEMBL4085557)

IC50: 45nMAssay Description:Inhibition of recombinant human GST-tagged Clk1 expressed in Escherichia coli using RS repeat substrate peptide after 15 mins in presence of [gamma-3...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 351 total ) | Next | Last >>

Filter my 351 hits

Targets 23▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 82
- Protein kinase C zeta type 53
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 44
- Dual specificity protein kinase CLK1 23
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase 22
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 16
- Dual specificity protein kinase CLK2 11
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 10
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 10
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 10
- cGMP-dependent 3',5'-cyclic phosphodiesterase 10
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 10
- Dual specificity protein kinase CLK1/CLK4 8
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 5
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 5
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 5
- Nitric oxide synthase, inducible 5
- Dual specificity protein kinase CLK4 5
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 5
- Serine/threonine-protein kinase haspin 3
- Alpha-synuclein 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 2
- ...
Publications 10▿
- J Med Chem 64: 4462-4477 (2021) 127
- J Med Chem 57: 6513-30 (2014) 58
- Eur J Med Chem 238: (2022) 33
- Eur J Med Chem 157: 1031-1050 (2018) 24
- Eur J Med Chem 45: 1278-86 (2010) 22
- J Med Chem 65: 14740-14763 (2022) 22
- J Med Chem 60: 5377-5391 (2017) 20
- Eur J Med Chem 158: 270-285 (2018) 20
- Eur J Med Chem 227: (2022) 17
- International Journal of Medicinal Chemistry 2011: 1-9 (2011) 8
Institutions 2▿
- German University In Cairo 271
- Saarland University 80
Affinity: 0.67 to 1.0E+6 nM▿
- IC50 346
- EC50 5
- Affinity ≤ nM
Xtal structures: 5
Docked structures: 3
Catalog Cmpds: 18