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Found 164 with Last Name = 'abraham' and Initial = 'rt'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50:  0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35593(pyrazolo pyrimidine, 25)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35589(pyrazolo pyrimidine, 21)
Affinity DataIC50:  0.320nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35594(pyrazolo pyrimidine, 27)
Affinity DataIC50:  0.340nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35578(pyrazolo pyrimidine, 10)
Affinity DataIC50:  0.380nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378663(CHEMBL1204015)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308156(CHEMBL592615 | N-[2-(Dimethylamino)ethyl]-4-({[4-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35591(pyrazolo pyrimidine, 23)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50:  0.460nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378662(CHEMBL1204014)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308156(CHEMBL592615 | N-[2-(Dimethylamino)ethyl]-4-({[4-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35580(pyrazolo pyrimidine, 13)
Affinity DataIC50:  0.520nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50378663(CHEMBL1204015)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308137(1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35590(pyrazolo pyrimidine, 22)
Affinity DataIC50:  0.610nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308137(1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308155(4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)pheny...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308136(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308136(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35586(pyrazolo pyrimidine, 26)
Affinity DataIC50:  0.830nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308147(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35588(pyrazolo pyrimidine, 20)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35584(pyrazolo pyrimidine, 17)
Affinity DataIC50:  1.10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308151(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308150(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50378662(CHEMBL1204014)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35579(pyrazolo pyrimidine, 6)
Affinity DataIC50:  1.40nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308148(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308155(4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)pheny...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308154(4-[3-{4-(4,6-Dimorpholino-1,3,5-triazin-2yl)-pheny...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35577(pyrazolo pyrimidine, 12)
Affinity DataIC50:  1.5nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308149(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308150(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308148(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308147(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308149(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35583(pyrazolo pyrimidine, 16)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35582(pyrazolo pyrimidine, 15)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308152(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308153(4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)pheny...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308151(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308140(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308143(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phe...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50308140(1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phen...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50:  4.30nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50:  4.60nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50308135(1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}ph...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
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