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Found 74 with Last Name = 'ahmed' and Initial = 'g'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16318(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0470nM ΔG°:  -58.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16319(3-({2-amino-5-cyano-6-[(2,2-dimethylpropyl)(methyl...)
Affinity DataKi:  0.0500nM ΔG°:  -58.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16329(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16317(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16320(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]p...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16330(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16325(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.410nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16324(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16323(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16322(3-{[5-cyano-6-(propylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  0.970nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16331(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16326(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16332(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataKi:  3.70nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16328(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16327(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16321(3-{[5-cyano-6-(methylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261565(CHEMBL4098239)
Affinity DataIC50:  7nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156754((S)-N-methoxy-4-methyl-3-(4-(methyl(neopentyl)amin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156743((S)-N-hydroxy-4-methyl-3-(4-(methyl(neopentyl)amin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156750(CHEMBL376506 | DEL-A, 5 | N-methoxy-4-methyl-3-(4-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156757((S)-4-methyl-3-(4-(methyl(neopentyl)amino)-6-(pyrr...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156741((S)-3-(4-(isobutyl(methyl)amino)-6-(pyrrolidin-3-y...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156755((S)-N-ethyl-4-methyl-3-(4-(methyl(neopentyl)amino)...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156737((S)-N-isopropyl-4-methyl-3-(4-(methyl(neopentyl)-a...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156738(3-(4-(1,4-diazepan-1-yl)-6-(methyl(neopentyl)amino...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156752(3-(4-(((1S,2R,5S)-6,6-dimethylbicyclo[3.1.1]heptan...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156742(CHEMBL222098 | N-methoxy-4-methyl-3-(4-(methyl(neo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156756((S)-N-benzyl-4-methyl-3-(4-(methyl(neopentyl)amino...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261578(CHEMBL4085932)
Affinity DataIC50:  65nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156747((S)-3-(4-(isobutylamino)-6-(pyrrolidin-3-ylamino)-...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156739(4-methyl-3-(4-(methyl(2-phenylpropyl)amino)-6-((S)...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156746((S)-N-cyclopentyl-4-methyl-3-(4-(methyl(neopentyl)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261559(CHEMBL4067116)
Affinity DataIC50:  100nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261561(CHEMBL4075710)
Affinity DataIC50:  110nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261577(CHEMBL4077445)
Affinity DataIC50:  120nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261563(CHEMBL4089618)
Affinity DataIC50:  129nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261562(CHEMBL4068479)
Affinity DataIC50:  198nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261581(CHEMBL4086863)
Affinity DataIC50:  202nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261575(CHEMBL4102621)
Affinity DataIC50:  210nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156749((S)-3-(4-(4-fluorophenethylamino)-6-(pyrrolidin-3-...)
Affinity DataIC50:  227nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261580(CHEMBL4100191)
Affinity DataIC50:  232nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156744((S)-3-(4-(cyclohexyl(methyl)amino)-6-(pyrrolidin-3...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261579(CHEMBL4064401)
Affinity DataIC50:  250nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261583(CHEMBL4081744)
Affinity DataIC50:  250nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261570(CHEMBL4071193)
Affinity DataIC50:  250nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50156748((S)-N-(2-methoxyethyl)-4-methyl-3-(4-(methyl(neope...)
Affinity DataIC50:  264nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Evestra

Curated by ChEMBL
LigandPNGBDBM50261585(CHEMBL4073866)
Affinity DataIC50:  290nMAssay Description:Inhibition of human CA2 catalytic activity pre-incubated for 15 mins followed by 4-NPA substrate addition and measured every 12 to 15 secs for 5 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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