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Found 109 with Last Name = 'alfieri' and Initial = 'r'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307941(CHEMBL592617 | N-(4-(3-Bromoanilino)quinazolin-6-y...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383051(CHEMBL2031302)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383049(CHEMBL2031300)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383047(CHEMBL2031298)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383052(CHEMBL2031303)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383046(CHEMBL2031297)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383054(CHEMBL2031305)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521039(CHEMBL4449681)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307940(CHEMBL603266 | N-(4-(3-Bromoanilino)quinazolin-6-y...)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307939(CHEMBL599863 | N-[2-[(4-(3-Bromoanilino)quinazolin...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50493387(CHEMBL2425736)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of wild type human EGFR tyrosine kinase assessed as Ulight-CAGAGAIETDKEYYTVKD phosphorylation after 15 mins by time-resolved fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383048(CHEMBL2031299)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383053(CHEMBL2031304)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521051(CHEMBL4439974)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521047(CHEMBL4530170)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of wild type human EGFR tyrosine kinase assessed as Ulight-CAGAGAIETDKEYYTVKD phosphorylation after 15 mins by time-resolved fluorometryMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521041(CHEMBL4562352)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521052(CHEMBL4526992)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50493385(CHEMBL2425735)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of wild type human EGFR tyrosine kinase assessed as Ulight-CAGAGAIETDKEYYTVKD phosphorylation after 15 mins by time-resolved fluorometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383056(CHEMBL2031307)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307936(CHEMBL599047 | N-(4-(3-Bromoanilino)quinazolin-6-y...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521048(CHEMBL4440618)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system after 1 hr by kinase trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50:  1.24nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383055(CHEMBL2031306)
Affinity DataIC50:  1.46nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50574082(CHEMBL4866162)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  1.69nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50493387(CHEMBL2425736)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383043(CHEMBL2031309)
Affinity DataIC50:  2.02nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383057(CHEMBL2031308)
Affinity DataIC50:  2.21nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50574082(CHEMBL4866162)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521047(CHEMBL4530170)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50493385(CHEMBL2425735)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50574076(CHEMBL4855850)
Affinity DataIC50:  6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521048(CHEMBL4440618)
Affinity DataIC50:  7nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307934(CHEMBL597200 | N-(4-(3-Bromoanilino)quinazolin-6-y...)
Affinity DataIC50:  8.43nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383046(CHEMBL2031297)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50307933(CHEMBL604914 | N-(4-(3-Bromoanilino)quinazolin-6-y...)
Affinity DataIC50:  9.25nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521050(CHEMBL4572315)
Affinity DataIC50:  11nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50521043(CHEMBL4556799)
Affinity DataIC50:  12nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  12nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by western blotMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50383044(CHEMBL2031311 | US10774068, Example 96 | US1142756...)
Affinity DataIC50:  12.5nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  13nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Parma

Curated by ChEMBL
LigandPNGBDBM50493385(CHEMBL2425735)
Affinity DataIC50:  14nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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