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Found 888 with Last Name = 'annedi' and Initial = 's'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50255365((+/-)-cis-N1-((3S,4S)-4-((6-amino-4-methylpyridin-...)
Affinity DataKi:  5nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  7nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50072408(CHEMBL228077)
Affinity DataKi:  100nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50072407(CHEMBL44833)
Affinity DataKi:  130nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  0.300nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  0.300nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  1.70nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  1.70nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Phoenix Molecular Design

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  2nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Phoenix Molecular Design

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  2nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM458758((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  6nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM342166((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  6nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM342166((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  8nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM458758((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  8nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  12nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111496(US8618286, 22)
Affinity DataIC50:  14nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286090((R)¿N-(1-(2-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  14nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  18nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  20nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286091((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  20nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50352593(CHEMBL1825174)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM286089((R)¿N-(1-(3-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)
Affinity DataIC50:  23nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Phoenix Molecular Design

US Patent
LigandPNGBDBM458758((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  23.6nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Phoenix Molecular Design

US Patent
LigandPNGBDBM342166((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  23.6nMAssay Description:Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111497(US8618286, 23)
Affinity DataIC50:  28nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50206074((+/-)-N-{2-[2-(1-methyl-pyrrolidin-2-yl)-ethylamin...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111490(US8618286, 16)
Affinity DataIC50:  34nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50401280(CHEMBL3216124)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM106707(CHEMBL1957358 | US8586620, 67)
Affinity DataIC50:  48nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50:  50nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50206073(CHEMBL233652 | N-[2-(2-pyridin-2-yl-ethylamino)-be...)
Affinity DataIC50:  50nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111498(US8618286, 24)
Affinity DataIC50:  50nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM106698(CHEMBL1957349 | US8586620, 42)
Affinity DataIC50:  51nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50:  56nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Neuraxon

US Patent
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  59nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50352592(CHEMBL1825173)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111482(US8618286, 8)
Affinity DataIC50:  60nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50352591(CHEMBL1825172)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50365335(CHEMBL1955937)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50379744(CHEMBL2011136)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111484(US8618286, 10)
Affinity DataIC50:  80nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50401282(CHEMBL3216566)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM111502(US8618286, 28)
Affinity DataIC50:  80nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50357692(CHEMBL1915288)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50206064(CHEMBL233857 | N-[2-(1-benzyl-piperidin-4-ylamino)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50352590(CHEMBL1825171)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM50357690(CHEMBL1915286)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Phoenix Molecular Designs

US Patent
LigandPNGBDBM458758((R)-1-benzyl-N-(9-methyl-6-oxo-6,7,8,9-tetrahydrop...)
Affinity DataIC50:  94nMAssay Description:Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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