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Found 111 with Last Name = 'apgar' and Initial = 'jm'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136294(US8853212, DDP-4 Inhibitor 10)
Affinity DataIC50:  0.170nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136295(US8853212, DDP-4 Inhibitor 11)
Affinity DataIC50:  0.460nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136291(US8853212, DDP-4 Inhibitor 7)
Affinity DataIC50:  0.5nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136293(US8853212, DDP-4 Inhibitor 9)
Affinity DataIC50:  0.600nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136298(US8853212, DDP-4 Inhibitor 14)
Affinity DataIC50:  0.700nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136297(US8853212, DDP-4 Inhibitor 13)
Affinity DataIC50:  0.700nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136296(US8853212, DDP-4 Inhibitor 12)
Affinity DataIC50:  1.10nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136300(US8853212, DDP-4 Inhibitor 16)
Affinity DataIC50:  1.5nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136292(US8853212, DDP-4 Inhibitor 8)
Affinity DataIC50:  1.60nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136299(US8853212, DDP-4 Inhibitor 15)
Affinity DataIC50:  1.70nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136285(US8853212, DDP-4 Inhibitor 1)
Affinity DataIC50:  2.30nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136290(US8853212, DDP-4 Inhibitor 6)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499796(CHEMBL3742110)
Affinity DataIC50:  2.99nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499806(CHEMBL3740011)
Affinity DataIC50:  3.05nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136286(US8853212, DDP-4 Inhibitor 2)
Affinity DataIC50:  3.40nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499797(CHEMBL3742052)
Affinity DataIC50:  7.32nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136301(US8853212, DDP-4 Inhibitor 17)
Affinity DataIC50:  8.10nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499793(CHEMBL3739474)
Affinity DataIC50:  9.53nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499808(CHEMBL3741296)
Affinity DataIC50:  11.5nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499809(CHEMBL3741220)
Affinity DataIC50:  13.2nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499807(CHEMBL3740280)
Affinity DataIC50:  14.1nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499799(CHEMBL3741985)
Affinity DataIC50:  22.2nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499794(CHEMBL3741163)
Affinity DataIC50:  24.5nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136287(US8853212, DDP-4 Inhibitor 3 | US8853212, DDP-4 I...)
Affinity DataIC50:  40nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136287(US8853212, DDP-4 Inhibitor 3 | US8853212, DDP-4 I...)
Affinity DataIC50:  49nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499811(CHEMBL3742174)
Affinity DataIC50:  56.5nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499805(CHEMBL3741171)
Affinity DataIC50:  71.9nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499792(CHEMBL3739756)
Affinity DataIC50:  74.8nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499810(CHEMBL3741086)
Affinity DataIC50:  81.8nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499804(CHEMBL3740861)
Affinity DataIC50:  81.9nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499795(CHEMBL3740165)
Affinity DataIC50:  86.1nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499787(CHEMBL3740212)
Affinity DataIC50:  86.6nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM136289(US8853212, DDP-4 Inhibitor 5)
Affinity DataIC50:  119nMpH: 7.5Assay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499801(CHEMBL3740840)
Affinity DataIC50:  341nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499788(CHEMBL3740729)
Affinity DataIC50:  577nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499800(CHEMBL3740534)
Affinity DataIC50:  634nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499790(CHEMBL3741728)
Affinity DataIC50:  813nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499798(CHEMBL3739429)
Affinity DataIC50:  1.19E+3nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499789(CHEMBL3741737)
Affinity DataIC50: >1.33E+3nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499791(CHEMBL3741042)
Affinity DataIC50:  1.41E+3nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499802(CHEMBL3740960)
Affinity DataIC50:  1.46E+3nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-D-glucan synthase catalytic subunit(Candida albicans)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50499803(CHEMBL3740167)
Affinity DataIC50: >1.42E+4nMAssay Description:Displacement of UDP-[3H]glucose from beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membranes incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM201007(US9540364, example 17)
Affinity DataEC50:  20nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM201008(US9540364, example 18)
Affinity DataEC50:  34nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM201009(US9540364, example 19)
Affinity DataEC50:  67nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM201010(US9540364, example 20)
Affinity DataEC50:  50nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM201011(US9540364, example 21)
Affinity DataEC50:  38nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM213186(US9290517, 14)
Affinity DataEC50:  29nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM213187(US9290517, 18)
Affinity DataEC50:  6nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM213188(US9290517, 71)
Affinity DataEC50:  10nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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