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Found 627 with Last Name = 'atwal' and Initial = 'ks'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004154(2-Butyl-4-chloro-6-methyl-1-[2'-(1H-tetrazol-5-yl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004155(2-Butyl-6-chloro-4,4-dimethyl-1-[2'-(1H-tetrazol-5...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225073((S)-2-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  4.71nMAssay Description:Inhibition of human factor 10a by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004164(2-Butyl-4-chloro-6-methyl-1-[2'-(1H-tetrazol-5-yl)...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)
Affinity DataKi:  9nMAssay Description:In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225053(2-(S)-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  10nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225049(2-(S)-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  14nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062397(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Affinity DataKi:  27nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225050((S)-2-amino-2-(3-hydroxy-adamantan-1-yl)-1-thiazol...)
Affinity DataKi:  28nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004153(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4-chlor...)
Affinity DataKi:  41nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281270(Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-8-me...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225045((S)-2-amino-2-(3-hydroxy-adamantan-1-yl)-1-pyrroli...)
Affinity DataKi:  49nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062402(1N-cyanoimino(tert-pentylamino)methyl-3-azido-4-io...)
Affinity DataKi:  57nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004160(CHEMBL145036 | Sodium; 4'-(2-butyl-6-chloro-5-etho...)
Affinity DataKi:  58nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062394(1N-cyanoimino(tert-pentylamino)methyl-4-iodoanilin...)
Affinity DataKi:  74nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004163(CHEMBL342287 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)
Affinity DataKi:  82nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281272((2R,3S)-5-(2-Dimethylamino-ethyl)-8-methoxy-2-(4-m...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataKi:  95nMAssay Description:In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062396(4-cyanoimino(1,2,2-trimethylpropylamino)methylamin...)
Affinity DataKi:  99nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225076((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  112nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  130nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004162(CHEMBL145276 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)
Affinity DataKi:  150nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225055((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  152nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062398(4-cyanoimino(tert-pentylamino)methylaminobenzonitr...)
Affinity DataKi:  160nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004156(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4-(4-ch...)
Affinity DataKi:  190nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225070((S)-2-amino-1-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-(3,...)
Affinity DataKi:  270nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50240750(()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...)
Affinity DataKi:  320nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062393(3-cyanoimino(1,2,2-trimethylpropylamino)methylamin...)
Affinity DataKi:  350nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225071((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  356nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataKi:  380nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062399(4-[tert-butylamino(cyanoimino)methylamino]benzonit...)
Affinity DataKi:  480nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016388(5-(2-Dimethylamino-ethyl)-4-methyl-2-(3-nitro-phen...)
Affinity DataKi:  505nMAssay Description:Inhibition of [3H]-diltiazem binding to calcium channels of guinea pig myocardiumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225077((2S,3S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)...)
Affinity DataKi:  530nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281271((2R,3S)-5-(2-Dimethylamino-ethyl)-2-(4-methoxy-phe...)
Affinity DataKi:  540nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225051((S)-2-amino-2-(3-hydroxy-5,7-dimethyl-adamantan-1-...)
Affinity DataKi:  607nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000383((3R,4R)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phe...)
Affinity DataKi:  650nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50062400(1N-cyanoimino(1,2,2-trimethylpropylamino)methylani...)
Affinity DataKi:  680nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225044((2S,3R)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)...)
Affinity DataKi:  731nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004157(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-6-methy...)
Affinity DataKi:  850nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225060((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  877nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004158(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4,6-dim...)
Affinity DataKi:  990nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225058((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225075((S)-1-((1S,5R)-2-aza-bicyclo[3.1.0]hexan-2-yl)-2-a...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  1.28E+3nMAssay Description:Inhibition of human TPA by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225046((S)-2-amino-2-(3-hydroxy-adamantan-1-yl)-1-(1H-iso...)
Affinity DataKi:  1.42E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004159(CHEMBL343622 | Sodium; 4'-(2-butyl-4-chloro-5-etho...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004165(CHEMBL144952 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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