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Found 200 with Last Name = 'baker' and Initial = 'sp'
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.720nMAssay Description:Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375517(CHEMBL411245)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  2.56nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  2.56nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375516(CHEMBL258759)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  2.93nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  3.77nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375515(CHEMBL410288)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  5.12nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225877((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((R)-tetrahyd...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375531(CHEMBL427737)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  12.6nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375532(CHEMBL262604)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225881((1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hyd...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  21.5nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375514(CHEMBL412104)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225880((1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hyd...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225883(CHEMBL391031 | endo-(2R,3R,4S,5R)-2-(6-(7-aza-bicy...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138530((2R,3R,5R)-2-Hydroxymethyl-5-{6-[(R)-(tetrahydro-f...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225885((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((R)-tetrahyd...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]ZM-241385 from adenosine A2A receptor expressed in PC12 cell membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375529(CHEMBL258489)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375528(CHEMBL260631)
Affinity DataKi:  122nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataKi:  136nM ΔG°:  -38.8kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225882((1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hyd...)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375533(CHEMBL263643)
Affinity DataKi:  173nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375530(CHEMBL260205)
Affinity DataKi:  283nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375525(CHEMBL262876)
Affinity DataKi:  285nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225878((R)-benzyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hy...)
Affinity DataKi:  288nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25398(Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...)
Affinity DataKi:  311nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375527(CHEMBL258972)
Affinity DataKi:  383nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375526(CHEMBL258760)
Affinity DataKi:  431nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25398(Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...)
Affinity DataKi:  436nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375519(CHEMBL279161)
Affinity DataKi:  590nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225876((1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hyd...)
Affinity DataKi:  783nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225879(1-((R)-3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydrox...)
Affinity DataKi:  803nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25396(Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...)
Affinity DataKi:  863nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50225884((R)-tert-butyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5...)
Affinity DataKi:  929nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor expressed in DDT1 MF2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25397((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi:  1.01E+3nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25399(Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...)
Affinity DataKi:  1.91E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25396(Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...)
Affinity DataKi:  1.91E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25394(Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...)
Affinity DataKi:  1.98E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50375518(CHEMBL411859)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Monash University

LigandPNGBDBM25399(Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...)
Affinity DataKi:  2.30E+3nM ΔG°:  -31.9kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [125I]-(-)iodopindolol binding from the beta2AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM25395((2R,3R,4S,5R)-2-{6-[(2-{[2-(3-amino-4-hydroxypheny...)
Affinity DataKi:  2.75E+3nM ΔG°:  -31.4kJ/molepH: 7.4 T: 2°CAssay Description:The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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