Affinity DataIC50: 4nMAssay Description:Inhibition of sheep COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of sheep COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of sheep COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of FLAP in human monocytes assessed as suppression of fMLP/LPS-stimulated cys-LT formation preincubated for 15 mins measured after 10 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of FLAP in human monocytes assessed as suppression of A23187-stimulated 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of LTC4 synthase in LPS/fMLP-stimulated human monocytes assessed as decrease in cys-LT formation pre-incubated with LPS for 30 mins and la...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of FLAP in human monocytes assessed as suppression of A23187-stimulated 5-LO product formation using 10 uM arachidonic acid as substrate p...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-LO in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of sheep COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of sheep COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of FLAP in A23187-stimulated human monocytes assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187 a...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of FLAP in human neutrophils assessed as suppression of A23187-stimulated 5-LO product formation using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LO in human leucocytes by measuring FLAP-dependent 5-LOproduct LTB4 in presence of calcium ionophore A23187More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of FLAP in human neutrophils assessed as suppression of A23187-stimulated 5-LO product formation using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair