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Found 256 with Last Name = 'barker' and Initial = 'r'
LigandPNGBDBM50150119(CHEMBL3769414)
Affinity DataIC50:  0.0580nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Mus musculus)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mouse UGT8 assessed as redcution in GalCer accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Mus musculus)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of mouse UGT8 assessed as redcution in SFT accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561671(CHEMBL4796521)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561669(CHEMBL4787939)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561671(CHEMBL4796521)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561670(CHEMBL4750073)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561669(CHEMBL4787939)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561664(CHEMBL4776963)
Affinity DataIC50:  1nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561670(CHEMBL4750073)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561672(CHEMBL4750432)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561663(CHEMBL4765010)
Affinity DataIC50:  2nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561663(CHEMBL4765010)
Affinity DataIC50:  2nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561672(CHEMBL4750432)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561664(CHEMBL4776963)
Affinity DataIC50:  3nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239931(CHEMBL4067995 | US10287286, Example 142)
Affinity DataIC50:  8nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239883(CHEMBL4090769 | US10287286, Example 5)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239889(CHEMBL4072842 | US10287286, Example 100)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29602(benzylidenehydrazine derivative, 19)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561665(CHEMBL4755797)
Affinity DataIC50:  18nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29593(benzylidenehydrazine derivative, 10)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29595(benzylidenehydrazine derivative, 12)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239888(CHEMBL4094292 | US10287286, Example 103)
Affinity DataIC50:  25nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239915(CHEMBL4067559 | US10287286, Example 6)
Affinity DataIC50:  34nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239937(CHEMBL4083851 | US10287286, Example 3)
Affinity DataIC50:  34nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29603(benzylidenehydrazine derivative, 20)
Affinity DataIC50:  36nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29599(benzylidenehydrazine derivative, 16)
Affinity DataIC50:  37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29596(benzylidenehydrazine derivative, 13)
Affinity DataIC50:  37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561665(CHEMBL4755797)
Affinity DataIC50:  37nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239890(CHEMBL4095005 | US10287286, Example 4)
Affinity DataIC50:  39nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29597(benzylidenehydrazine derivative, 14)
Affinity DataIC50:  41nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29594(benzylidenehydrazine derivative, 11)
Affinity DataIC50:  43nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561667(CHEMBL4757982)
Affinity DataIC50:  43nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29607(benzylidenehydrazine derivative, 24)
Affinity DataIC50:  45nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50059026(5'-Methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spi...)
Affinity DataIC50:  48nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561667(CHEMBL4757982)
Affinity DataIC50:  48nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29598(benzylidenehydrazine derivative, 15)
Affinity DataIC50:  49nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239921(CHEMBL4075128 | US10287286, Example 7)
Affinity DataIC50:  50nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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