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Found 102 with Last Name = 'barton' and Initial = 'j'
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279769((S)-1-{(R)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13281(4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonyl...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081009(CHEMBL85938 | Thieno[3,2-b]pyridine-2-sulfonic aci...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13279(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Affinity DataKi:  7nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279767(CHEMBL268343 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279765(CHEMBL215405 | {2-{4-[5-Carboxymethoxy-4-(5-cycloh...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14058(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Affinity DataKi:  22nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081011(3-[(S)-2-Oxo-3-(thieno[3,2-b]pyridine-2-sulfonylam...)
Affinity DataKi:  26nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13280(3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-...)
Affinity DataKi:  47nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081008(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1,6-...)
Affinity DataKi:  80nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060330(CHEMBL265335 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279770(2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279771(CHEMBL217744 | [4-Benzyloxy-5-{5-benzyloxy-4-[5-be...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081001(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Affinity DataKi:  180nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279770(2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-...)
Affinity DataKi:  190nMAssay Description:Binding Affinity of the compound to inhibit HLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279766(CHEMBL213783 | {2-{5-Benzyloxy-4-[4-(5-benzyloxy-4...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060332(CHEMBL215927)
Affinity DataKi:  240nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081004(7-Methoxy-naphthalene-2-sulfonic acid [1-(4-amino-...)
Affinity DataKi:  250nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081007(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Affinity DataKi:  370nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279771(CHEMBL217744 | [4-Benzyloxy-5-{5-benzyloxy-4-[5-be...)
Affinity DataKi:  750nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13280(3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-...)
Affinity DataKi:  850nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081003(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Affinity DataKi:  890nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060332(CHEMBL215927)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081010(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-ch...)
Affinity DataKi: >1.20E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081012(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-hy...)
Affinity DataKi: >1.20E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081005(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Affinity DataKi:  1.20E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060329(CHEMBL385442 | {2-{4-[5-Carboxymethoxy-4-(5-hydrox...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060331(CHEMBL412744 | bis-[4-tert-Butyl-2-[5-tert-butyl-3...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081001(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Affinity DataKi:  1.35E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279767(CHEMBL268343 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  1.40E+3nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13280(3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-...)
Affinity DataKi:  1.40E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279766(CHEMBL213783 | {2-{5-Benzyloxy-4-[4-(5-benzyloxy-4...)
Affinity DataKi:  1.50E+3nMpH: 7.5Assay Description:Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50366615(CHEMBL1907672)
Affinity DataKi:  1.60E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060330(CHEMBL265335 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  1.70E+3nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50366615(CHEMBL1907672)
Affinity DataKi: >2.90E+3nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081001(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Affinity DataKi: >2.90E+3nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081004(7-Methoxy-naphthalene-2-sulfonic acid [1-(4-amino-...)
Affinity DataKi: >2.90E+3nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081007(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Affinity DataKi: >2.90E+3nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081005(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Affinity DataKi: >2.90E+3nMAssay Description:In vitro evaluation of inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081005(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Affinity DataKi: >4.00E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50366615(CHEMBL1907672)
Affinity DataKi: >4.00E+3nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279768((2-{2-Benzyloxy-4-[2-benzyloxy-4-(2-benzyloxy-5-ca...)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279767(CHEMBL268343 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279766(CHEMBL213783 | {2-{5-Benzyloxy-4-[4-(5-benzyloxy-4...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279765(CHEMBL215405 | {2-{4-[5-Carboxymethoxy-4-(5-cycloh...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279768((2-{2-Benzyloxy-4-[2-benzyloxy-4-(2-benzyloxy-5-ca...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279770(2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060330(CHEMBL265335 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060329(CHEMBL385442 | {2-{4-[5-Carboxymethoxy-4-(5-hydrox...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060329(CHEMBL385442 | {2-{4-[5-Carboxymethoxy-4-(5-hydrox...)
Affinity DataKi: >1.50E+4nMpH: 7.5Assay Description:Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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