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Found 4151 with Last Name = 'beck' and Initial = 'h'
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  1.30nM ΔG°:  -52.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM520995((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20061(5-Substituted-6-chlorouracil, 7a | 6-chloro-5-(cyc...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20069(5-Substituted-6-chlorouracil, 10e | 6-chloro-5-(th...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20065(5-Substituted-6-chlorouracil, 10a | 6-chloro-5-phe...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20073(5-Substituted-6-chlorouracil, 13c | 6-chloro-5-[(1...)
Affinity DataKi:  410nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20062(5-Substituted-6-chlorouracil, 7b | 6-chloro-5-(cyc...)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20064(5-Substituted-6-chlorouracil, 7d | 6-chloro-5-[(2E...)
Affinity DataKi:  490nM ΔG°:  -37.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20075(6-Fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione, 21 |...)
Affinity DataKi:  500nM ΔG°:  -37.4kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20072(5-Substituted-6-chlorouracil, 13b | 5-[(1E)-but-1-...)
Affinity DataKi:  630nM ΔG°:  -36.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20068(5-Substituted-6-chlorouracil, 10d | 6-chloro-5-(4-...)
Affinity DataKi:  710nM ΔG°:  -36.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20056(5-Substituted-6-chlorouracil, 5c | 5-butyl-6-chlor...)
Affinity DataKi:  1.03E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20059(5-Substituted-6-chlorouracil, 5f | 6-chloro-5-hept...)
Affinity DataKi:  1.06E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20071(5-Substituted-6-chlorouracil, 13a | 6-chloro-5-[(1...)
Affinity DataKi:  1.17E+3nM ΔG°:  -35.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20076(6-Bromo-5-phenylpyrimidine-2,4(1H,3H)-dione, 23 | ...)
Affinity DataKi:  1.21E+3nM ΔG°:  -35.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20066(5-Substituted-6-chlorouracil, 10b | 6-chloro-5-(3,...)
Affinity DataKi:  1.74E+3nM ΔG°:  -34.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20058(5-Substituted-6-chlorouracil, 5e | 6-chloro-5-hexy...)
Affinity DataKi:  1.83E+3nM ΔG°:  -34.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20070(5-Substituted-6-chlorouracil, 10f | 6-chloro-5-(py...)
Affinity DataKi:  3.01E+3nM ΔG°:  -32.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20063(5-Substituted-6-chlorouracil, 7c | 6-chloro-5-(pro...)
Affinity DataKi:  3.34E+3nM ΔG°:  -32.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20057(5-Substituted-6-chlorouracil, 5d | 6-chloro-5-pent...)
Affinity DataKi:  3.67E+3nM ΔG°:  -32.3kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20067(5-Substituted-6-chlorouracil, 10c | 6-chloro-5-(na...)
Affinity DataKi:  4.59E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20060(5-Substituted-6-chlorouracil, 5g | 5-benzyl-6-chlo...)
Affinity DataKi:  4.65E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20055(5-Substituted-6-chlorouracil, 5b | 6-chloro-5-prop...)
Affinity DataKi:  5.81E+3nM ΔG°:  -31.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312773((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D3 rceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312771((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312772((R)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312773((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312774((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312776((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312777((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312778((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312779((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312780((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312766((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312767((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312780((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312766((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312767((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312768((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312769((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312771((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312772((R)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312773((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312774((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312775((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312776((S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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