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Found 42 with Last Name = 'blundell' and Initial = 'tl'
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50192452(2'-monophosphoadenosine 5'-diphosphoribose)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM11941(2,5-ADP | ADENOSINE-2 -5 -DIPHOSPHATE | {[(2R,3R,4...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataKi:  6.10E+5nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKi:  1.05E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  6.30E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM14671(Fragment 1 | Phosphate | phosphoric acid)
Affinity DataKi:  2.70E+7nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527800(CHEMBL4591748)
Affinity DataIC50:  250nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Cambridge Crystallographic Data Centre

Curated by ChEMBL
LigandPNGBDBM50180855(CHEMBL3818314)
Affinity DataIC50:  250nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527797(CHEMBL4435863)
Affinity DataIC50:  310nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527801(CHEMBL4444080)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527798(CHEMBL4439827)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527796(CHEMBL4473331)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527802(CHEMBL4541593)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527799(CHEBI:60704 | CHEMBL2387748)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228833((E)-3-(Furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-...)
Affinity DataKd:  2.00E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228834(3-(Furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one (8))
Affinity DataKd:  2.20E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50370754(CHEMBL252929)
Affinity DataKd:  1.53E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50370755(Myprozine | NICOTINAMIDE_ADENINE_DINUCLEOTIDE | Na...)
Affinity DataKd:  6.90E+6nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50192448([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataKd:  6.30E+6nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50192451(CHEMBL213053 | NADP+)
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50192452(2'-monophosphoadenosine 5'-diphosphoribose)
Affinity DataKd:  6.10E+4nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd: >5.00E+6nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50192456([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataKd:  6.60E+4nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM92459(CHEMBL384759 | GDP | Guanosine Diphosphate)
Affinity DataKd:  3.73E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM11941(2,5-ADP | ADENOSINE-2 -5 -DIPHOSPHATE | {[(2R,3R,4...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataKd:  1.30E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228832(N-(Cyclopentylmethyl)pyrrolidine-1-sulfonamide (6))
Affinity DataKd:  2.00E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228831(1-((2-Cyclopentylethyl)sulfonyl)pyrrolidine (5))
Affinity DataKd:  1.60E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228830(N-(Cyclopentylmethyl)cyclopentanecarboxamide (4))
Affinity DataKd:  1.10E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228829(N-(Cyclopentylmethyl)pyrrolidine-1-carboxamide (3))
Affinity DataKd:  6.00E+3nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228828(Cyclopentylmethyl pyrrolidine-1-carboxylate (2))
Affinity DataKd:  1.50E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM228827(3-Cyclopentyl-1-(pyrrolidin-1-yl)propan-1-one (1))
Affinity DataKd:  1.20E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM50159250(2-Naphthol | 2-naphthalenol | CHEMBL14126 | Naphth...)
Affinity DataKd:  4.60E+5nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM23450(1-Naphthalenol | 1-Naphthol | CHEMBL122617 | Napht...)
Affinity DataKd:  4.30E+5nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM93044(L-Methyl ester tryptophan, 8)
Affinity DataKd:  5.70E+5nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM50335100(1,3-benzothiazol-2-amine | 2-Aminobenzothiazole, 6...)
Affinity DataKd:  7.30E+5nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM24627(1H-indazole | Indazole, 5 | Indazole, 6)
Affinity DataKd:  1.00E+6nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM93043(4-Methylester indole, 4)
Affinity DataKd:  1.30E+6nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM93042(Indole, 2)
Affinity DataKd:  2.10E+6nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50422885(CHEMBL2364573 | NADPH)
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University Of Cambridge

LigandPNGBDBM32212(1H-indol-5-ol | cid_16054)
Affinity DataKd:  2.10E+6nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair