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Found 386 with Last Name = 'boursier' and Initial = 'e'
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  0.251nMAssay Description:Binding affinity to full-length BRD4 short isoform (unknown origin) by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1/2 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of human BRD3 bromodomain 1 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: <1nMAssay Description:Inhibition of human BRPF3 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: <1.30nMAssay Description:Inhibition of human BRD7 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  2nMAssay Description:Inhibition of human BRD3 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human BRD2 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human BRD4 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: <4nMAssay Description:Inhibition of human BRPF1 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2685(3-(1H-indol-3-yl)-4-{1-[2-(piperidin-2-yl)ethyl]-1...)
Affinity DataIC50:  5nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50:  10nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118668(CHEMBL3617086)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2694(3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...)
Affinity DataIC50:  13nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118669(CHEMBL3617083)
Affinity DataIC50:  13nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118637(CHEMBL3617084)
Affinity DataIC50:  13nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365264(CHEMBL1738926)
Affinity DataIC50:  15.5nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd4 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118672(CHEMBL3617082)
Affinity DataIC50:  16nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118665(CHEMBL3617085)
Affinity DataIC50:  16nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118524(CHEMBL3617080)
Affinity DataIC50:  20nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118523(CHEMBL3617079)
Affinity DataIC50:  25nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118588(CHEMBL3617095)
Affinity DataIC50:  25nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2691(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)
Affinity DataIC50:  26nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365264(CHEMBL1738926)
Affinity DataIC50:  28.4nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd3 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365264(CHEMBL1738926)
Affinity DataIC50:  29.9nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd2 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118665(CHEMBL3617085)
Affinity DataIC50:  32nMAssay Description:Inhibition of BCATm in differentiated primary human adipocytes assessed as remaining leucine level by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118610(CHEMBL3617102)
Affinity DataIC50:  32nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50:  32.5nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd2 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50:  36.1nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd4 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118607(CHEMBL3617098)
Affinity DataIC50:  40nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2681(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1...)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50:  42.4nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd3 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2692(3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...)
Affinity DataIC50:  45nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118521(CHEMBL3617077)
Affinity DataIC50:  50nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173927(CHEMBL3808902)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118637(CHEMBL3617084)
Affinity DataIC50:  50nMAssay Description:Inhibition of BCATm in differentiated primary human adipocytes assessed as remaining leucine level by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118522(CHEMBL3617078)
Affinity DataIC50:  50nMAssay Description:Inhibition of human cloned BCATm expressed in Escherichia coli BL21 DE3 assessed as L-glutamate production from alpha-ketoglutarate after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  50nMAssay Description:Inhibition of BRDT (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118669(CHEMBL3617083)
Affinity DataIC50:  50nMAssay Description:Inhibition of BCATm in differentiated primary human adipocytes assessed as remaining leucine level by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173927(CHEMBL3808902)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2686(3-(1H-indol-3-yl)-4-{1-[3-(piperazin-1-yl)propyl]-...)
Affinity DataIC50:  52nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173928(CHEMBL3809839)
Affinity DataIC50:  63nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173926(CHEMBL3808971)
Affinity DataIC50:  63nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, cytosolic(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118665(CHEMBL3617085)
Affinity DataIC50:  63nMAssay Description:Inhibition of BCATc (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118668(CHEMBL3617086)
Affinity DataIC50:  63nMAssay Description:Inhibition of BCATm in differentiated primary human adipocytes assessed as remaining leucine level by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50118524(CHEMBL3617080)
Affinity DataIC50:  63nMAssay Description:Inhibition of BCATm in differentiated primary human adipocytes assessed as remaining leucine level by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173928(CHEMBL3809839)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173926(CHEMBL3808971)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2693(3-(1H-indol-3-yl)-4-{1-[3-(morpholin-4-yl)propyl]-...)
Affinity DataIC50:  70nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBranched-chain-amino-acid aminotransferase, mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50173923(CHEMBL3810317)
Affinity DataIC50:  79nMAssay Description:Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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