TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 220nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 890nMAssay Description:Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cellsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 1.70E+3nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 2.00E+4nMAssay Description:Antagonist activity at human wild type CXCR4 expressed in COS7 cells coexpressing G protein Gqi4myr assessed as inhibition of CXCL12-induced phosphat...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymp...More data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymp...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibitory activity against CX3C chemokine receptor 4-specific monoclonal antibody 12G5 (mAb-12G5) binding to human chemokinin receptor CXCR4 in lymp...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 119nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of anti-CXCR4 12G5 monoclonal antibody to CXCR4 in human SUP-T1 cells pretreated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 206nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of anti-CXCR4 12G5 monoclonal antibody to CXCR4 in human SUP-T1 cells pretreated for 30 mins by flow cytometryMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 442nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 514nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Antagonistic activity was determined by measuring the ability to inhibit superoxide production(stimulated by fMLF) using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 973nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium fluxMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Johnson Matthey Biomedical Research
Curated by ChEMBL
Johnson Matthey Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards fMLF receptor using human neutrophilsMore data for this Ligand-Target Pair