Compile Data Set for Download or QSAR
maximum 50k data
Found 1957 with Last Name = 'brown' and Initial = 'pj'
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  0.800nM IC50:  4nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  1.30nM IC50:  5nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  3nM IC50:  9nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataKi:  3.70nMAssay Description:Non-competitive inhibition of lysine methyltransferase G9a (unknown origin) using SAM as substrate by Michaelis-Menten kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50180955(CHEMBL3818617)
Affinity DataKi:  8nMAssay Description:Competitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using varying levels of Btn-Ahx-GSRAHSSHLKSKK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  11nM IC50:  30nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50511923(CHEMBL4463793)
Affinity DataKi:  16nMAssay Description:Inhibition of human PRMT6 pre-incubated for 1 to 30 mins using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillati...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  17nM IC50:  42nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  23nM IC50:  83nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50180955(CHEMBL3818617)
Affinity DataKi:  28nMAssay Description:Uncompetitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using fixed levels of Btn-Ahx-GSRAHSSHLKSKK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50201571(CHEMBL3934996)
Affinity DataKi:  50nMAssay Description:Competitive inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  55nM IC50:  119nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]pentazocine from guinea pig sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]alpha-methylhistamine from human histamine H3 receptor expressed HEK Flp-In cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi:  110nM IC50:  230nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  120nM IC50:  250nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  120nM IC50:  260nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074672((R)-2-(4-Methoxy-phenylsulfanylcarbonylamino)-pent...)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178102(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Affinity DataKi:  550nM IC50:  1.10E+3nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  950nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074680(2-p-Tolylsulfanylcarbonylamino-pentanedioic acid |...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074674(2-(3-Methoxy-phenylsulfanylcarbonylamino)-pentaned...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi:  1.50E+3nM IC50:  3.00E+3nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of varying levels of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074673(2-(3-Amino-phenylsulfanylcarbonylamino)-pentanedio...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074679(2-(4-Amino-phenylsulfanylcarbonylamino)-pentanedio...)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi: >1.00E+4nM IC50: >2.00E+4nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi: >3.75E+4nM IC50: >7.50E+4nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178101(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Affinity DataKi: >5.00E+4nM IC50: >1.00E+5nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50074678(2-(1-Oxy-pyridin-4-ylsulfanylcarbonylamino)-pentan...)
Affinity DataKi:  1.65E+5nMAssay Description:Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataIC50:  0.400nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 416 amino acid residues) using [3H]-SAM assessed as inhibition of nucleosome methylation incu...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446378(CHEMBL3109639)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of SUMO-His-tagged WDR5 (unknown origin) interaction with MLL1 assessed as displacement of fluorescence labelled Ac-ARA peptide substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446386(CHEMBL3109631)
Affinity DataIC50:  1nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353121(CHEMBL1829295)
Affinity DataIC50:  2nMAssay Description:Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040583((R)-4-(1,3-Dioxo-5-propoxy-1,3-dihydro-isoindol-2-...)
Affinity DataIC50:  2.10nMAssay Description:Activity against human gelatinase (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50095537(CHEMBL3590526 | US9598381, 1a (S enantiomer))
Affinity DataIC50:  2.80nMAssay Description:Inhibition of SMYD2 (unknown origin) using biotinylated GSRAHSSHLKSKKGQSTSRH as substrate assessed as incorporation of tritium labeled methyl group f...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) interaction with MLL1 assessed as displacement of 5-Lys-FAM peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446376(CHEMBL3109630)
Affinity DataIC50:  3nMAssay Description:Inhibition of G9a (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442106(CHEMBL2441078)
Affinity DataIC50:  3nMAssay Description:Inhibition of lysine methyltransferase G9a (unknown origin) using [3H]-SAM as substrate after 0.25 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446376(CHEMBL3109630)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446380(CHEMBL3109637)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040607((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50:  3.80nMAssay Description:Activity against human gelatinase (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human PRMT4 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT4 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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