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Found 1115 with Last Name = 'buckman' and Initial = 'b'
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17280(1-[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluo...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17284(2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-diflu...)
Affinity DataKi:  0.110nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17284(2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-diflu...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066635((4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difl...)
Affinity DataKi:  0.240nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066619(({2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluo...)
Affinity DataKi:  0.260nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  0.270nM ΔG°:  -54.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066634((4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difl...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066641((2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066623(CHEMBL72318 | {[2-(5-Carbamimidoyl-2-hydroxy-pheno...)
Affinity DataKi:  0.410nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066623(CHEMBL72318 | {[2-(5-Carbamimidoyl-2-hydroxy-pheno...)
Affinity DataKi:  0.410nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50071415(3-[9-Benzyl-6-(5-carbamimidoyl-2-hydroxy-phenoxy)-...)
Affinity DataKi:  0.420nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066639((2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3...)
Affinity DataKi:  0.430nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066625(CHEMBL120438 | {4-[2-(5-Carbamimidoyl-2-hydroxy-ph...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066628((2S,4R)-4-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6...)
Affinity DataKi:  0.710nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066638(3-[6-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-diflu...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17281(7-({2-[(1-ethanimidoylpiperidin-4-yl)oxy]-9H-carba...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066638(3-[6-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-diflu...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066637(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066637(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113913(3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  3nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066622(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethy...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066622(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethy...)
Affinity DataKi:  3.90nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113894(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-carbami...)
Affinity DataKi:  6nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50071050(3-amidinobenzyl phenyl ether | CHEMBL294703)
Affinity DataKi:  6.80nMAssay Description:Binding affinity of the compound was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113925(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(2-meth...)
Affinity DataKi:  8nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113883(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1,4-di...)
Affinity DataKi:  8.40nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066636(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  9nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066636(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  9nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50071419(3-[9-Benzyl-2-(5-carbamimidoyl-2-hydroxy-phenoxy)-...)
Affinity DataKi:  10nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50370088(CHEMBL84437)
Affinity DataKi:  12nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Binding affinity of the compound was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  13nMAssay Description:Binding affinity of the compound was evaluated against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113909(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066627(3-[6-(2-Amino-5-carbamimidoyl-phenoxy)-3,5-difluor...)
Affinity DataKi:  14nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066627(3-[6-(2-Amino-5-carbamimidoyl-phenoxy)-3,5-difluor...)
Affinity DataKi:  14nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex

LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50071417(3-[4-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-oxo-5,6...)
Affinity DataKi:  19nMAssay Description:Compound was tested for inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50113865(3-[6-(5-Carbamimidoyl-2,3-dihydroxy-phenoxy)-3,5-d...)
Affinity DataKi:  23nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066640(3-{6-[3-amino(imino)methylphenoxy]-3,5-difluoro-2-...)
Affinity DataKi:  24nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066617(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-imidazo...)
Affinity DataKi:  26nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066617(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-imidazo...)
Affinity DataKi:  26nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  30nMAssay Description:Compound was tested for inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
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