Compile Data Set for Download or QSAR
maximum 50k data
Found 265 with Last Name = 'cansfield' and Initial = 'a'
LigandPNGBDBM391716(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50539955(CHEMBL4638938)
Affinity DataKi:  0.0251nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391726(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
LigandPNGBDBM391723(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391725(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391724(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM391718(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50539954(CHEMBL4636143)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11439(4-({5-[(4-aminocyclohexyl)amino]-3-bromopyrazolo[1...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11429(4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyra...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389412(CHEMBL2064508)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11430(4-({5-[(4-aminocyclohexyl)amino]-3-cyanopyrazolo[1...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389427(CHEMBL2064507)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389431(CHEMBL2064501)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11431(4-({5-[(4-aminocyclohexyl)amino]-3-chloropyrazolo[...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11432(4-({5-[(4-aminocyclohexyl)amino]-3-bromopyrazolo[1...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11440(5-N-(4-aminocyclohexyl)-3-chloro-7-N-[4-(thiophene...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTORC1 in HEK293T/17 cells assessed as reduction in S6RP phosphorylation at Ser-240/244 residue after 2 hrs by sandwich immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTORC2 in HEK293T/17 cells assessed as reduction in Akt phosphorylation at Ser-473 residue after 2 hrs by sandwich immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389391(CHEMBL2064512)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11441(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11435(4-({5-[(4-aminocyclohexyl)oxy]-3-(propan-2-yl)pyra...)
Affinity DataIC50:  17nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389420(CHEMBL2064571)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387529(CHEMBL2059909)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Roche Products

Curated by ChEMBL
LigandPNGBDBM50112960((1S,3R)-3-({(1S,9S)-9-[(S)-2-Acetylamino-3-(4-phos...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity towards p56 Lck tyrosine kinase SH2 domain using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389428(CHEMBL2064511)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389408(CHEMBL2064500)
Affinity DataIC50:  39.8nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389395(CHEMBL2064482)
Affinity DataIC50:  39.8nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11428(4-({5-[(4-aminocyclohexyl)amino]-3-(propan-2-yl)py...)
Affinity DataIC50:  59nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11433(4-[(5-{[4-(ethylamino)cyclohexyl]amino}-3-(propan-...)
Affinity DataIC50:  61nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389407(CHEMBL2064499)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387545(CHEMBL2059907)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11434(4-[(5-{[4-(diethylamino)cyclohexyl]amino}-3-(propa...)
Affinity DataIC50:  92nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387528(CHEMBL2059908)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Roche Products

Curated by ChEMBL
LigandPNGBDBM50112980((1R,3R)-3-({(1S,9S)-9-[(S)-2-Acetylamino-3-(4-phos...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity towards p56 Lck tyrosine kinase SH2 domain using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389431(CHEMBL2064501)
Affinity DataIC50: >100nMAssay Description:Inhibition of PI3Kalpha by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389427(CHEMBL2064507)
Affinity DataIC50: >100nMAssay Description:Inhibition of PI3Kalpha by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389415(CHEMBL2064514)
Affinity DataIC50:  100nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389419(CHEMBL2064570)
Affinity DataIC50:  126nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389427(CHEMBL2064507)
Affinity DataIC50:  126nMAssay Description:Inhibition of PI3Kdelta by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389393(CHEMBL2064480)
Affinity DataIC50:  158nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389412(CHEMBL2064508)
Affinity DataIC50:  158nMAssay Description:Inhibition of PI3Kalpha by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389414(CHEMBL2064513)
Affinity DataIC50:  158nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389400(CHEMBL2064489)
Affinity DataIC50:  200nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389406(CHEMBL2064498)
Affinity DataIC50:  200nMAssay Description:Inhibition of PI3Kalpha by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  226nMAssay Description:Inhibition of mTOR in human whole blood assessed as reduction in alphaCD3/alphaCD28 and IL-2-induced IFNgamma secretion preincubated for 1 hr followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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