TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of [3H]mazindol binding to the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 42nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 76nMAssay Description:Displacement of [3H]-DTG from sigma 2 receptor (unknown origin) after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 212nMAssay Description:Inhibition of [3H]dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Mixed non-competitive inhibition of full length recombinant human PTP1B assessed as enzyme-substrate-inhibitor complex using pNPP as substrate by dou...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Competitive inhibition of full length recombinant human PTP1B assessed as enzyme-inhibitor complex using pNPP as substrate by double reciprocal plot ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 1.50E+3nMAssay Description:Mixed non-competitive inhibition of full length recombinant human PTP1B assessed as enzyme-substrate-inhibitor complex using pNPP as substrate by dou...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 2.30E+3nMAssay Description:Mixed non-competitive inhibition of full length recombinant human PTP1B assessed as enzyme-substrate-inhibitor complex using pNPP as substrate by dou...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataKi: 3.92E+3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 4.40E+3nMAssay Description:Competitive inhibition of full length recombinant human PTP1B assessed as enzyme-inhibitor complex using pNPP as substrate by double reciprocal plot ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataKi: 9.90E+3nMAssay Description:Competitive inhibition of full length recombinant human PTP1B assessed as enzyme-inhibitor complex using pNPP as substrate by double reciprocal plot ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 7.0 T: 2°CAssay Description:The MMP assay were performed evaluating the ability of compounds 1a-6a and 1b-6b to prevent the hydrolysis of the fluorescence-quenched peptide subst...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of MMP13 catalytic domain (unknown origin) assessed as reduction in hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured f...More data for this Ligand-Target Pair
Affinity DataIC50: 158nMpH: 7.0 T: 2°CAssay Description:The MMP assay were performed evaluating the ability of compounds 1a-6a and 1b-6b to prevent the hydrolysis of the fluorescence-quenched peptide subst...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 520nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of MMP3 catalytic domain (unknown origin) assessed as reduction in hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured fo...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as inhibition of PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.06E+3nMAssay Description:Inhibition of MMP3 catalytic domain (unknown origin) assessed as reduction in hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured fo...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of full length recombinant human PTP1B using pNPP as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as inhibition of PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.19E+3nMAssay Description:Inhibition of MMP3 catalytic domain (unknown origin) assessed as reduction in hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured fo...More data for this Ligand-Target Pair