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Found 380 with Last Name = 'chamberlain' and Initial = 't'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049025(4-[6-(4-Methoxy-phenyl)-spiro[2.4]hept-5-en-5-yl]-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049011(4-[6-(3,4-Dichloro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049014(4-[6-(4-Chloro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049042(4-[6-(4-Trifluoromethyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049038(5-(4-Chloro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049030(5-(4-Methanesulfonyl-phenyl)-6-p-tolyl-spiro[2.4]h...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049033(4-[6-(3-Chloro-4-fluoro-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049037(5-(4-Methanesulfonyl-phenyl)-6-(4-trifluoromethyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049040(4-[6-(3-Bromo-4-methoxy-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049029(4-[6-(3-Chloro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049023(4-[6-(3-Fluoro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049028(5-[6-(4-Methanesulfonyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50029614((SC-57666)1-[2-(4-fluorophenyl)-1-cyclopentenyl]-4...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049010(4-[6-(3,4-Difluoro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049024(4-[6-(4-Fluoro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049018(5-(3,4-Dichloro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044356(5-Butyl-2-phenethyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049013(5-(3,4-Difluoro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044345(5-Butyl-2-(2-hydroxy-2-phenyl-ethyl)-4-[2'-(1H-tet...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049022(6-(4-Fluoro-phenyl)-7-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049027(4-[6-(3,5-Dichloro-4-methoxy-phenyl)-spiro[2.4]hep...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044334(5-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049034(5-(4-Methanesulfonyl-phenyl)-6-(4-methoxy-phenyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049025(4-[6-(4-Methoxy-phenyl)-spiro[2.4]hept-5-en-5-yl]-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50285518(4-[3-(3-Fluoro-4-methoxy-phenyl)-benzofuran-2-yl]-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against human recombinant cyclooxygenase-2 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50285514(4-[3-(4-Fluoro-phenyl)-1H-inden-2-yl]-benzenesulfo...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against human recombinant cyclooxygenase-2 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044355(2,5-Dibutyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044355(2,5-Dibutyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044357(5-Butyl-2-pentyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049031(5-(3,5-Dichloro-4-methoxy-phenyl)-6-(4-methanesulf...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50046078(5-[4'-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-biph...)
Affinity DataIC50:  6.5nMAssay Description:Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]-angiotensin II binding to rat uterine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049021(5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50285514(4-[3-(4-Fluoro-phenyl)-1H-inden-2-yl]-benzenesulfo...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibitory activity against human recombinant cyclooxygenase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50285517(4-[3-(4-Fluoro-phenyl)-benzofuran-2-yl]-benzenesul...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibitory activity against human recombinant cyclooxygenase-2 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044348(5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049041(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044367(5-Butyl-2-hexyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044361(CHEMBL67764 | {3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044338(6-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044366(5-Butyl-2-sec-butyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049035(5-(3-Fluoro-4-methoxy-phenyl)-6-(4-methanesulfonyl...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50285516(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-1...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against human recombinant cyclooxygenase-2 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50283548(1-{(5S,8S)-3-Butyl-1-chloro-5-[2'-(2H-tetrazol-5-y...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044369(5-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044365(5-Butyl-2-(2-methoxy-2-phenyl-ethyl)-4-[2'-(2H-tet...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049032(5-(3-Bromo-4-methoxy-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50283551(1-{(5S,8S)-3-Butyl-5-[2'-(2H-tetrazol-5-yl)-biphen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044346(5-Butyl-2-propyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Searle R&D

Curated by ChEMBL
LigandPNGBDBM50044335(5-Butyl-2-cyclopropylmethyl-4-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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