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Found 573 with Last Name = 'clark' and Initial = 'ma'
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034711((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  0.800nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  1.5nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034706((1R,2R)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  11nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034707(4-((2S,3R)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  33nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034709((1S,2S)-2-(1H-Imidazol-4-yl)-cyclopentylamine | CH...)
Affinity DataKi:  740nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568221(CHEMBL4854947)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568222(CHEMBL4867490)
Affinity DataKi:  1.93E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034710((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-cyclohexylam...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034713((1S,2S)-2-(1H-Imidazol-4-yl)-1-methyl-cyclohexylam...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50568220(CHEMBL4873655)
Affinity DataKi:  9.27E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells assessed as inhibitory constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034707(4-((2S,3R)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding afinity against H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding afinity against H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding afinity against H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of recombinant wild type human N-terminal His6-tagged BTK expressed in baculovirus incubated for 20 mins by TR-FRET based competitive bind...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50:  0.550nMT: 2°CAssay Description:The BTK time-resolved FRET-based competitive binding assay and cell-based BTK assays have been previously described.[Xu et al., J.Pharmacol. Exp. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50566635(CHEMBL4875337)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563635(CHEMBL4777640)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MMP-13 using 5-FAM-TPGPLGL[Dap- (DNP)]ARRK(5-TAMRA)-amide as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50559893(CHEMBL4749356)
Affinity DataIC50:  1nMAssay Description:Inhibition of His-tagged human recombinant soluble epoxide hydrolase pre-incubated for 15 mins before Epoxy-fluor7 substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50566638(CHEMBL4862566)
Affinity DataIC50:  1nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
LigandPNGBDBM50540028(CHEMBL4635769)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of TACE using Mca-PLAQAV-Dpa-RSSSR-NH2 as substrate preincubated 15 mins measured every 30 sec for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448871(CHEMBL3125101)
Affinity DataIC50:  2nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50540030(CHEMBL4633392)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540025(CHEMBL4639517)
Affinity DataIC50:  2nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Praecis Pharmaceuticals

LigandPNGBDBM36462(3-(4-((3-(Aminomethyl)cyclohexyl)methylamino)-6-(3...)
Affinity DataIC50: <2nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Praecis Pharmaceuticals

LigandPNGBDBM36463(3-(4-((3-(Aminomethyl)cyclohexyl)methylamino)-6-(3...)
Affinity DataIC50: <2nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448867(CHEMBL3125235)
Affinity DataIC50:  2nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50559894(CHEMBL4793243)
Affinity DataIC50:  2nMAssay Description:Inhibition of His-tagged human recombinant soluble epoxide hydrolase pre-incubated for 15 mins before Epoxy-fluor7 substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50540029(CHEMBL4648587)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ADAMTS-4 using WAAG-3R as substrate preincubated for 15 mins measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448875(CHEMBL3125266)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448880(CHEMBL3125261)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448888(CHEMBL3125253)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50539700(CHEMBL4637413)
Affinity DataIC50:  3nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50566636(CHEMBL4870025)
Affinity DataIC50:  3nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK C481S mutant expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448868(CHEMBL3125104)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563640(CHEMBL4746916)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of His6/TEV fused-GST-tagged Flt3 (unknown origin) (H564 to S993 residues) using Axltide (CKKSRGDYMTMQJ-acid) peptide as substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of GST-tagged AXL (unknown origin) (464 to 485 residues) using Axltide (CKKSRGDYMTMQJG-acid) peptide as substrate preincubated for 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50540026(CHEMBL4645846)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells using synthetic substrate FS-3 by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM225238(BTK inhibitor, 3)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged BTK expressed in baculovirus infected in Sf9 cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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