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Found 271 with Last Name = 'cockcroft' and Initial = 'xl'
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077057(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  24nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077058(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  26nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077049(CHEMBL24186 | Methyl-carbamic acid 2-{1-[(S)-3-ben...)
Affinity DataKi:  38nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077053((2-{1-[(S)-3-Benzothiazol-2-yl-2-(3,3-dimethyl-1,2...)
Affinity DataKi:  52nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077044((2-{1-[(S)-3-Benzothiazol-2-yl-2-(3,3-dimethyl-1,2...)
Affinity DataKi:  56nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077043(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  65nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077056(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  79nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077042(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  93nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077052(1N-(2-{1-[3-benzo[d][1,3]thiazol-2-yl-2-(3,3-dimet...)
Affinity DataKi:  119nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077046(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  182nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077050(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  240nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077047(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  350nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077051(CHEMBL28272 | N-(2-{1-[(S)-3-Benzothiazol-2-yl-2-(...)
Affinity DataKi:  654nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077054(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077048(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077055(3-{1-[(S)-3-Benzothiazol-2-yl-2-(3,3-dimethyl-1,2,...)
Affinity DataKi:  7.83E+3nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Center

Curated by ChEMBL
LigandPNGBDBM50077045(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  3.83E+4nMAssay Description:Inhibition of human thrombin (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
Kudos Pharmaceuticals

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1nMAssay Description:A FlashPlate scintillation proximity assay has been used to identify inhibitors of PARP-2. PARP-2 protein (recombinant) was bound down by a PARP-2 sp...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27545(4-[(4-fluoro-3-{[4-(pyridin-2-yl)piperazin-1-yl]ca...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27546(4-[(3-{[4-(pyrimidin-2-yl)piperazin-1-yl]carbonyl}...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27567(4-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27570(4-[(4-fluoro-3-{[4-(oxolan-3-ylcarbonyl)piperazin-...)
Affinity DataIC50:  2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27547(4-[(4-fluoro-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27569(4-[(4-fluoro-3-{[4-(oxolan-2-ylcarbonyl)piperazin-...)
Affinity DataIC50:  3nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50165496(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  3.80nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27563(4-[(3-{[4-(cyclopropylmethyl)piperazin-1-yl]carbon...)
Affinity DataIC50:  4nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50165488(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50165497(3-[2-Fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylme...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177440(4-(3-(1-cyclohexyl-1,4-diazepane-4-carbonyl)-4-flu...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177446(4-(3-(1-(cyclopropylmethyl)-1,4-diazepane-4-carbon...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177458(4-(4-fluoro-3-(1-propyl-1,4-diazepane-4-carbonyl)b...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27543(4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27553(4-({4-fluoro-3-[(4-phenylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27562(4-({3-[(4-butylpiperazin-1-yl)carbonyl]-4-fluoroph...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27565(4-({4-fluoro-3-[(4-propanoylpiperazin-1-yl)carbony...)
Affinity DataIC50:  5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177441(4-(3-(1-cyclohexyl-1,4-diazepane-4-carbonyl)benzyl...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177453(4-{3-[4-(biphenyl-4-sulfonyl)-[1,4]diazepane-1-car...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27551(4-[(4-fluoro-3-{[4-(morpholin-4-ylcarbonyl)piperaz...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27555(4-({3-[(4-benzoylpiperazin-1-yl)carbonyl]-4-fluoro...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27560(4-({3-[(4-ethylpiperazin-1-yl)carbonyl]-4-fluoroph...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27561(4-({4-fluoro-3-[(4-propylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27564(4-({3-[(4-acetylpiperazin-1-yl)carbonyl]-4-fluorop...)
Affinity DataIC50:  6nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50165498(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  6.80nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM50177462(4-(3-(1-ethyl-1,4-diazepane-4-carbonyl)-4-fluorobe...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Kudos Pharmaceuticals

LigandPNGBDBM27535(4-[(4-fluoro-3-{[4-(2-hydroxyethyl)-1,4-diazepan-1...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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