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Found 29 with Last Name = 'colayco' and Initial = 's'
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM88776(2-[4-[(Z)-[5-(4-chlorophenyl)-6-isopropoxycarbonyl...)
Affinity DataKi:  690nMAssay Description:Competitive inhibition of recombinant HePTP expressed in Escherichia coli by Michaelis-Menten kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  340nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM88776(2-[4-[(Z)-[5-(4-chlorophenyl)-6-isopropoxycarbonyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378898(CHEMBL1672292)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378899(CHEMBL1672293)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  2.30E+3nMAssay Description:BRCC36 activity was measured using 1 nM purified BRISC complex and 80 nM di-ubiquitin substrate DiUbK63TAMRA (UF-310, Boston Biochem). TAMRA fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50:  2.40E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336847(2-(4-((5-(2-chlorophenyl)-6-(ethoxycarbonyl)-7-met...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378898(CHEMBL1672292)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTAM-binding protein(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  4.50E+3nMAssay Description:AMSH activity was measured using 10 nM purified AMSH (E-548B, Boston Biochem) and 80 nM di-ubiquitin substrate DiUbK63TAMRA (UF-310, Boston Biochem)....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336848(2-(4-((6-(ethoxycarbonyl)-5-(3-methoxyphenyl)-7-me...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336847(2-(4-((5-(2-chlorophenyl)-6-(ethoxycarbonyl)-7-met...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378899(CHEMBL1672293)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336848(2-(4-((6-(ethoxycarbonyl)-5-(3-methoxyphenyl)-7-me...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM88776(2-[4-[(Z)-[5-(4-chlorophenyl)-6-isopropoxycarbonyl...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  3.00E+4nMpH: 7.5Assay Description:Csn5 activity was measured using purified CSN complex and the fluorescent substrate OGNedd8–SCFSkp2, in which a unique cysteine engineered into ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378899(CHEMBL1672293)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336847(2-(4-((5-(2-chlorophenyl)-6-(ethoxycarbonyl)-7-met...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM88776(2-[4-[(Z)-[5-(4-chlorophenyl)-6-isopropoxycarbonyl...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  4.28E+4nMpH: 7.0 T: 2°CAssay Description:Assays were carried out in 100 mM sodium phosphate, pH 7.0 buffer using 96-well Clear UV Plate (Corning UV Transparent Microplates; catalog #3635). A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50378898(CHEMBL1672292)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336849(CHEMBL1672296 | ethyl 7-methyl-3-oxo-5-(thiophen-2...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant VHR expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336849(CHEMBL1672296 | ethyl 7-methyl-3-oxo-5-(thiophen-2...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant HePTP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in white NUNC 96-well plates as previously described [Puerta et al., J. Biol. Inorg. Chem., 11:131-138]. Each well containe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: >5.00E+4nMpH: 8.0 T: 2°CAssay Description:Assays were run in 50 mM HEPES (pH 8.0). A BioTek Synergy H4 microplate sample processor was used. The compounds were incubated with protein (final c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in white NUNC 96-well plates as previously described [Puerta et al., J. Biol. Inorg. Chem., 11:131-138]. Each well containe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336848(2-(4-((6-(ethoxycarbonyl)-5-(3-methoxyphenyl)-7-me...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50336849(CHEMBL1672296 | ethyl 7-methyl-3-oxo-5-(thiophen-2...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant MKP3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
California Institute Of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: >2.00E+5nMpH: 8.0 T: 2°CAssay Description:The enzyme was diluted with 25 mM Tris-Cl, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, pH 8.0 buffer and its activity was measured by using S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed