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Found 102 with Last Name = 'dandliker' and Initial = 'pj'
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151405(CHEMBL3775211 | US10189819, Example 79)
Affinity DataKi:  11nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human factor 10a using n-Acetyl-KPR-AFC as substrate preinubated for 30 mins followed by substrate addition measured after 1 hr by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201303(1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151406(CHEMBL3774670)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201323(1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201330(1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201330(1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201303(1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...)
Affinity DataIC50:  8nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201307(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201323(1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201314(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125977(CHEMBL3627897)
Affinity DataIC50:  10nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201327(1-(4-(4-amino-7-(4-hydroxyphenyl)thieno[3,2-c]pyri...)
Affinity DataIC50:  11nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201319(1-(4-(4-amino-7-(3-(methylcarbamoyl)phenyl)thieno[...)
Affinity DataIC50:  11nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153888(CHEMBL3774998)
Affinity DataIC50:  11nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201302(1-(4-(4-amino-7-phenylthieno[3,2-c]pyridin-3-yl)ph...)
Affinity DataIC50:  13nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201318(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201308(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201320(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  16nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201308(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  21nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201311(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  22nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201328(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-1-m...)
Affinity DataIC50:  23nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201310(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201322(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Affinity DataIC50:  26nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201325(1-(4-(4-amino-2-methylthieno[3,2-c]pyridin-3-yl)ph...)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201327(1-(4-(4-amino-7-(4-hydroxyphenyl)thieno[3,2-c]pyri...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201309(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  30nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201307(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201310(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201302(1-(4-(4-amino-7-phenylthieno[3,2-c]pyridin-3-yl)ph...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201301(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  38nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201314(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201305(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  45nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201320(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201309(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201319(1-(4-(4-amino-7-(3-(methylcarbamoyl)phenyl)thieno[...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201317(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Affinity DataIC50:  56nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201311(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201301(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  61nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153887(CHEMBL3775906)
Affinity DataIC50:  64nMAssay Description:Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201317(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201304(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  75nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214078(5-(4-bromophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214076(6-methyl-1-phenyl-5-(piperidin-1-yl)-1H-pyrazolo[3...)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201315(2-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-N-m...)
Affinity DataIC50:  94nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50214074(3-(5-(4-chlorophenyl)-6-methyl-4-oxo-4,5-dihydropy...)
Affinity DataIC50:  127nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201322(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-p...)
Affinity DataIC50:  141nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201318(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-(...)
Affinity DataIC50:  147nMAssay Description:Inhibition of human KDR phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201331(1-(4-(4-aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-o...)
Affinity DataIC50:  152nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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