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Found 77 with Last Name = 'de fusco' and Initial = 'c'
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581709(CHEMBL5075691)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  17nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  22nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50252622(CHEMBL4070389)
Affinity DataIC50:  370nMAssay Description:Inhibition of CK2alpha (unknown origin) using RRRADDSDDDD as substrate after 40 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha/beta(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50252622(CHEMBL4070389)
Affinity DataIC50:  670nMAssay Description:Binding affinity to CK2alpha/beta (unknown origin) expressed in Escherichia coli BL21(DE3) by ITCMore data for this Ligand-Target Pair
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581695(CHEMBL5082697)
Affinity DataIC50:  740nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581701(CHEMBL5081076)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590137(CHEMBL5198078)
Affinity DataIC50:  5.00E+3nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590138(CHEMBL5201730)
Affinity DataIC50:  6.00E+3nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581707(CHEMBL5086019)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581686(CHEMBL5090541)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581708(CHEMBL5084354)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590134(CHEMBL5180335)
Affinity DataIC50:  1.10E+4nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590135(CHEMBL5180822)
Affinity DataIC50:  1.60E+4nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590136(CHEMBL5203610)
Affinity DataIC50:  1.90E+4nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581710(CHEMBL5081015)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of hERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of hERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of hERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of hERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581703(CHEMBL5091875)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581689(CHEMBL5082669)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581702(CHEMBL5088337)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581698(CHEMBL5078640)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50590133(CHEMBL5184713)
Affinity DataIC50:  8.60E+4nMAssay Description:Negative allosteric modulation activity at CK2alpha (unknown origin) assessed as inhibition of CK2alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581682(CHEMBL5078655)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581687(CHEMBL5092214)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581688(CHEMBL5087166)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581690(CHEMBL5090243)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581705(CHEMBL5094549)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581704(CHEMBL5086613)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581700(CHEMBL5086150)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581699(CHEMBL5091008)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581697(CHEMBL5088701)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581696(CHEMBL5070989)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581694(CHEMBL5078702)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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