Compile Data Set for Download or QSAR
maximum 50k data
Found 1937 with Last Name = 'dehaven' and Initial = 'r'
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007377(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0540nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  0.0590nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093964(CHEMBL313484 | N-Methyl-N-((S)-1-phenyl-2-pyrrolid...)
Affinity DataKi:  0.0640nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093969(CHEMBL82919 | N-Methyl-2-(3-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.0650nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  0.0740nMAssay Description:Binding affinity towards cloned human Opioid receptor kappa 1 in CHO cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093958(2-(2-Amino-3,4-dichloro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0860nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093966(2-(3,4-Dichloro-2-nitro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0910nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093970(2-(3,4-Dichloro-2-dimethanesulfonylamino-phenyl)-N...)
Affinity DataKi:  0.0960nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176375(2-(3,4-dichlorophenylamino)-N-((S)-2-((S)-3-hydrox...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50093962(CHEMBL87306 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50090003(CHEMBL405190 | Tyr-Gly-[D-Ala]-Phe-Leu-Arg-Arg-Ile...)
Affinity DataKi:  0.150nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176369(CHEMBL201884 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50377009(CHEMBL257140)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50155498((S)-3-(3,4-Dichloro-phenyl)-1-[(S)-2-((S)-3-hydrox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176370(CHEMBL201572 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50010702(CHEMBL411557 | DYNORPHIN(1-17)-OH | Dynorphin A (1...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50377005(CHEMBL402135)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50128091(CHEMBL265813 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Affinity DataKi:  0.230nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205684(CHEMBL230288 | N1-((S)-2-((S)-3-hydroxypyrrolidin-...)
Affinity DataKi:  0.270nMAssay Description:Agonist activity at human kappa opioid receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50160834(CHEMBL183248 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  0.310nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377016(CHEMBL402820)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50176374(CHEMBL382932 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50155494(3-(3,4-Dichloro-phenyl)-1-(1-phenyl-2-pyrrolidin-1...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50128074(CHEMBL269483 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Affinity DataKi:  0.350nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160840(CHEMBL365486 | N-[(S)-1-(3-Methanesulfonylamino-ph...)
Affinity DataKi:  0.360nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.360nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.370nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50176373(2-(2-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50176365(CHEMBL201905 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50166621(CHEMBL191987 | N-[(S)-2-((S)-3-Hydroxy-pyrrolidin-...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM86965((S)-5-amino-2-((S)-2-(((3R,4R)-4-(3-hydroxyphenyl)...)
Affinity DataKi:  0.410nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093968(CHEMBL87207 | N-Methyl-2-(2-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.410nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50252953(CHEMBL494479 | N,N-Diethyl-4-(6-hydroxyspiro[chrom...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160832(CHEMBL181279 | N-[1-(3-Hydroxy-phenyl)-2-pyrrolidi...)
Affinity DataKi:  0.440nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50128078(CHEMBL2369408 | Tyr-Gly-Pro-Phe-Leu-Arg-Arg-Arg-Ar...)
Affinity DataKi:  0.440nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM86964(2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199910(3-((7R,8R,9alphaR)-7,8-dimethyl-2-(2-chlorobenzyl)...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160842(CHEMBL362248 | N-[(S)-1-(3-aminosulfonylamino-phen...)
Affinity DataKi:  0.480nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM86968((S)-6-amino-2-((S)-2-(((3R,4R)-4-(3-hydroxyphenyl)...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50136591(3-[(3R,4R)-3,4-Dimethyl-1-(3,5,5-trimethyl-hexyl)-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50176367(2-(3-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377008(CHEMBL254959)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50205686(CHEMBL230607 | N1-((S)-2-((S)-3-hydroxypyrrolidin-...)
Affinity DataKi:  0.530nMAssay Description:Agonist activity at human kappa opioid receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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