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Found 340 with Last Name = 'deprez-poulain' and Initial = 'r'
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50462575(CHEMBL4238121)
Affinity DataKi:  29nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProthrombin(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514426(CHEMBL4574713)
Affinity DataKi:  50nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514409(CHEMBL4549938)
Affinity DataKi:  600nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514425(CHEMBL4462026)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to Staphylococcus aureus biotin protein ligaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD kinase 1(Listeria monocytogenes serovar 1/2a (strain ATCC B...)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514423(CHEMBL4552749)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of Listeria monocytogenes NAD kinase assessed as suppression of reduced NADP formation by yeast glucose-6-phosphate dehydrogenase coupled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM23234(1,2,5-oxadiazole, OXD2 | 4-amino-1,2,5-oxadiazole-...)
Affinity DataKi:  4.20E+5nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50232690(4-Aminomethyl-Benzamidine | CHEMBL187301)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514419(CHEMBL4454339)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514420(CHEMBL4459159)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514421(CHEMBL4438181)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514422(CHEMBL4466928)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514412(CHEMBL4462216)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514424(CHEMBL4452459)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514411(CHEMBL4574617)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514410(CHEMBL4566571)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514418(CHEMBL4572188)
Affinity DataKi:  5.50E+6nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50351798(CHEMBL1824184)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50525490(CHEMBL4437643)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50206554(CHEMBL219777 | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123594((7-Chloro-quinolin-4-yl)-{3-[4-(3-dibutylamino-pro...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50056302(1-Butyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLuciferin 4-monooxygenase(Photinus pyralis)
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514408(CHEMBL4435351)
Affinity DataIC50:  10nMAssay Description:Inhibition of Photinus pyralis luciferase using ATP and D-luciferin in presence of Coenzyme A and DL-cysteine by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50206558(CHEMBL375521 | N-hydroxy-N'-(4-phenyl-butyl)-2-[1-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123579(CHEMBL345958 | [3-(4-{3-[Bis-(4-nitro-benzyl)-amin...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123587((7-Chloro-quinolin-4-yl)-(3-{4-[3-(cyclopropylmeth...)
Affinity DataIC50:  23.3nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50409777(CHEMBL2111198)
Affinity DataIC50:  23.5nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123575((3-{4-[3-(Bis-cyclopropylmethyl-amino)-propyl]-pip...)
Affinity DataIC50:  27.1nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50131276(CHEMBL328470 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against mammalian Aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human erythrocyte carbonic anhydrase-2 assessed as hydrolysis of 4-nitrophenylacetateMore data for this Ligand-Target Pair
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123577(CHEMBL152862 | Cyclopropanecarboxylic acid (3-{4-[...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123561(CHEMBL149751 | N-(3-(4-(3-(7-chloroquinolin-4-ylam...)
Affinity DataIC50:  34.2nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123569(CHEMBL357111 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Affinity DataIC50:  35.6nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123558((7-Chloro-quinolin-4-yl)-(3-{4-[3-(3-phenoxy-benzy...)
Affinity DataIC50:  37.5nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123571((7-Chloro-quinolin-4-yl)-(3-{4-[3-(4-nitro-benzyla...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123562(CHEMBL152635 | N-(3-(4-(3-(7-chloroquinolin-4-ylam...)
Affinity DataIC50:  40.2nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50206550(2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123565((7-Chloro-quinolin-4-yl)-[3-(4-{3-[(quinolin-4-ylm...)
Affinity DataIC50:  42.5nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123572((3-{4-[3-(Bis-quinolin-4-ylmethyl-amino)-propyl]-p...)
Affinity DataIC50:  43.4nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50197503(CHEMBL425291 | N-hydroxy-2-isobutyl-N'-(3-phenoxy-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50197497(2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide ...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123613(CHEMBL152886 | [3-(4-{3-[Bis-(4-methoxy-benzyl)-am...)
Affinity DataIC50:  47.8nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus infected insect cells using L-arginine-7-amido-4-methylcoumarine as substra...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Mus musculus (Mouse))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50:  50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Univ. Lille

Curated by ChEMBL
LigandPNGBDBM50514416(CHEMBL4466030)
Affinity DataIC50:  50nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123582(CHEMBL422682 | N-(3-(4-(3-(7-chloroquinolin-4-ylam...)
Affinity DataIC50:  50.6nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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