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Found 826 with Last Name = 'devadas' and Initial = 'b'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346920(CHEMBL1795686)
Affinity DataKi:  6nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346919(CHEMBL1795685)
Affinity DataKi:  17nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034993((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...)
Affinity DataKi:  31nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034993((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...)
Affinity DataKi:  31nMAssay Description:The Compound was tested for the inhibition potency against C. albicans N-myristoyltransferase (NMT) and reported as apparent KiMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi:  40nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034988(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)
Affinity DataKi:  70nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034988(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)
Affinity DataKi:  90nMAssay Description:Apparent binding affinity against Human NMT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470170(CHEMBL54883)
Affinity DataKi:  130nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataKi:  193nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470169(CHEMBL294596)
Affinity DataKi:  590nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470171(CHEMBL299249)
Affinity DataKi:  760nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470171(CHEMBL299249)
Affinity DataKi:  4.20E+3nMAssay Description:Apparent binding affinity against Human NMT.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50291976(6-Amino-2-(2-{2-[2-[2-(2-amino-propionylamino)-4-m...)
Affinity DataKi:  1.53E+4nMAssay Description:The Compound was tested for the inhibition potency against C. albicans N-myristoyltransferase (NMT) and reported as apparent KiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi: >4.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)
Affinity DataIC50:  0.170nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM470468(1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-[4-(4-...)
Affinity DataIC50:  0.170nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM303543(US10138229, Example 54 | US10266513, Example 127 |...)
Affinity DataIC50:  0.180nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM303543(US10138229, Example 54 | US10266513, Example 127 |...)
Affinity DataIC50:  0.180nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209482((3S)-3-(5-chloro-2-hydroxy-3-methylphenyl)-3-(2-(3...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209479((beta1S)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377842(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Affinity DataIC50:  0.25nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377842(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Affinity DataIC50:  0.25nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209459((3R)-3-(2-(3-amino-5-(5-hydroxy-1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209446((3S)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-h...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209471((3S)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377707(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Affinity DataIC50:  0.370nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377707(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Affinity DataIC50:  0.370nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377839(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Affinity DataIC50:  0.380nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377839(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Affinity DataIC50:  0.380nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM470355((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-di...)
Affinity DataIC50:  0.400nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209441((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377831(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(phenylthio...)
Affinity DataIC50:  0.400nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377831(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(phenylthio...)
Affinity DataIC50:  0.400nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209461((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377722(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377850(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Affinity DataIC50:  0.410nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377850(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Affinity DataIC50:  0.410nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377734(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluoro-4...)
Affinity DataIC50:  0.430nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377734(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluoro-4...)
Affinity DataIC50:  0.430nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377754(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-methoxy...)
Affinity DataIC50:  0.440nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377754(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-methoxy...)
Affinity DataIC50:  0.440nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377827(5-amino-1-[(3R*,6S*)-1-cyano-6-methylpiperidin-3-y...)
Affinity DataIC50:  0.460nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377827(5-amino-1-[(3R*,6S*)-1-cyano-6-methylpiperidin-3-y...)
Affinity DataIC50:  0.460nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377859(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-{4-[(...)
Affinity DataIC50:  0.480nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM470491(1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-{4-[(5...)
Affinity DataIC50:  0.480nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377778((R)-5-amino-3-(4-(2-chlorobenzyl)phenyl)-1-(1-cyan...)
Affinity DataIC50:  0.540nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377778((R)-5-amino-3-(4-(2-chlorobenzyl)phenyl)-1-(1-cyan...)
Affinity DataIC50:  0.540nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209450((beta1R)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377775((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(3-meth...)
Affinity DataIC50:  0.600nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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