Affinity DataKi: 0.0150nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,V571I](Human immunodeficiency virus type 1)
Merck Research Laboratories
Merck Research Laboratories
Affinity DataKi: 0.0520nM ΔG°: -59.7kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0620nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,L565M](Human immunodeficiency virus type 1)
Merck Research Laboratories
Merck Research Laboratories
Affinity DataKi: 0.114nM ΔG°: -57.7kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.125nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.240nMAssay Description:Dissociation constant obtained by inhibition of Wild-type proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,I539L](Human immunodeficiency virus type 1)
Merck Research Laboratories
Merck Research Laboratories
Affinity DataKi: 0.323nM ΔG°: -55.1kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity towards thrombin was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories
Merck Research Laboratories
Affinity DataKi: 0.358nM ΔG°: -54.8kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity towards thrombin was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity towards thrombin was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.520nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587,L512I](Human immunodeficiency virus type 1)
Merck Research Laboratories
Merck Research Laboratories
Affinity DataKi: 0.585nM ΔG°: -53.6kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.760nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 0.920nMAssay Description:Compound was tested for inhibition against rat Bradykinin receptor B1More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.33nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.37nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair